Effect of Prostaglandins on the Production of Interleukin-2

  • R. S. Rappaport
  • G. R. Dodge
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


A substantial body of evidence implicates prostaglandins as potent, local regulators of the immune response (1). It is well documented, for example, that prostaglandins, especially of the E-series, inhibit lectin or antigen-induced lymphocyte proliferation in vitro (2–5). Recently, it has become evident that T-cell proliferation is dependent on the production and utilization of a soluble protein known as T-cell growth factor (TCGF) or Interleukin-2 (IL-2) (6–8). Current evidence suggests that IL-2 is produced by one subset of T-lymphocytes (producer cells) and that it acts upon another subset of T-lymphocytes (responder cells via specific IL-2 receptors (9,10). The precise sequence of events which regulate the production of IL-2 and the development of specific receptors are not completely understood.


Responder Cell Grand Island Biological Prostaglandin Synthetase Inhibitor Normal Human Lymphocyte Adherent Cell Population 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • R. S. Rappaport
    • 1
  • G. R. Dodge
    • 1
  1. 1.Wyeth Laboratories, Inc.PhiladelphiaUSA

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