Genetic Disorders of Granulocyte Function: What they Tell Us about Normal Mechanisms

  • Richard K. Root
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


Clinically significant genetic defects of phagocyte function have been most clearly defined for polymorphonuclear leukocytes (PMN). Several important lessons have been learned from an analysis of these defects. These include:
  1. 1)

    Defining the role of oxidative metabolism in the microbicidal activity of PMNs;

  2. 2)

    determining the existence and activity of “back-up” killing mechanisms when deletions in normal pathways occur, and;

  3. 3)

    discerning the importance of PMNs relative to other cells in host defense against different microorganisms.



Respiratory Burst Chronic Granulomatous Disease Microbicidal Activity Chronic Granulomatous Disease Patient Human Polymorphonuclear Leukocyte 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Richard K. Root
    • 1
  1. 1.Department of Internal MedicineYale UniversityNew HavenUSA

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