Advertisement

Interferon-Induced Augmentation of Natural Killer Cell Activity by Splenocytes from Leukemia Virus Immunosuppressed Mice

  • Steven Specter
  • Mauro Bendinelli
  • William I. Cox
  • Herman Friedman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)

Abstract

Interactions of Friend leukemia virus (FLV) and immune responsiveness in mice has been studied extensively over the past decade (4). In most circumstances FLV has been shown to depress cellular and humoral immunity. However, the role of these depressed responses in the pathogenesis of this virus infection is not known. In this regard, our laboratory recently began investigation of natural killer (NK) cell activity in FLV infected BALB/c mice.

Keywords

Spleen Cell Natural Killer Cell Activity Natural Killer Activity Spleen Cell Culture Splenic Natural Killer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Brunner, K.T., Mavel, J., Cerotinni, J.C. and Chapius, B. (1968). Quantitative assay of the lytic action of immune lymphoid cells on 51Cr — labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. Immunol. 14:181–195.Google Scholar
  2. 2.
    Herberman, R.B., Holden, H.T., Varesio, L., Taniyama, T., Puccetti, P., Kirchner, H., Gerson, J., White, S. and Keisari, Y. (1980). Immunologic reactivity of lymphoid cells in tumors. Contemp. Topics Immunobiol. 10:61–78.Google Scholar
  3. 3.
    Kiessling, R., Klein, E., Pross, H. and Wigzell, H. (1975). Natural killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell. Eur. J. Immunol. 5: 117–121.PubMedCrossRefGoogle Scholar
  4. 4.
    Specter, S. and Friedman, H. (1978). Viruses and the immune response. Pharmac. Ther. A 2:595–622.Google Scholar
  5. 5.
    Welsh, R.M., Jr. and Doe, W.F. (1980). Cytotoxic cells induced during lymphocytic chorromeningitis virus infection of mice; Natural killer cell activity in cultured spleen leukocytes concomitant with T-cell dependent immune interferon production. Infect. Immunity 30:473–483.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Steven Specter
    • 1
  • Mauro Bendinelli
    • 1
  • William I. Cox
    • 1
  • Herman Friedman
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of South Florida, College of MedicineTampaUSA

Personalised recommendations