Interferon-Induced Augmentation of Natural Killer Cell Activity by Splenocytes from Leukemia Virus Immunosuppressed Mice
Interactions of Friend leukemia virus (FLV) and immune responsiveness in mice has been studied extensively over the past decade (4). In most circumstances FLV has been shown to depress cellular and humoral immunity. However, the role of these depressed responses in the pathogenesis of this virus infection is not known. In this regard, our laboratory recently began investigation of natural killer (NK) cell activity in FLV infected BALB/c mice.
KeywordsSpleen Cell Natural Killer Cell Activity Natural Killer Activity Spleen Cell Culture Splenic Natural Killer Cell
Unable to display preview. Download preview PDF.
- 1.Brunner, K.T., Mavel, J., Cerotinni, J.C. and Chapius, B. (1968). Quantitative assay of the lytic action of immune lymphoid cells on 51Cr — labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. Immunol. 14:181–195.Google Scholar
- 2.Herberman, R.B., Holden, H.T., Varesio, L., Taniyama, T., Puccetti, P., Kirchner, H., Gerson, J., White, S. and Keisari, Y. (1980). Immunologic reactivity of lymphoid cells in tumors. Contemp. Topics Immunobiol. 10:61–78.Google Scholar
- 4.Specter, S. and Friedman, H. (1978). Viruses and the immune response. Pharmac. Ther. A 2:595–622.Google Scholar
- 5.Welsh, R.M., Jr. and Doe, W.F. (1980). Cytotoxic cells induced during lymphocytic chorromeningitis virus infection of mice; Natural killer cell activity in cultured spleen leukocytes concomitant with T-cell dependent immune interferon production. Infect. Immunity 30:473–483.Google Scholar