Genetically Controlled Resistance to Viruses
Historically, the first demonstrations of the existence of host genes that could control resistance to disease induced by an animal virus were reported independently by Lynch and Hughes (1) and Webster and Clow (2) in 1936. Subsequently, a number of other genes have been identified in various strains of inbred mice, each of which confers resistance to a specific type of virus infection (3,4,5). Since different families of viruses vary greatly in their modes of replication, it would be expected a priori that the various resistance gene products would also differ in their mechanisms of action. Host resistance genes may act on a particular virus infection at the level of receptors, intracellular replication, interferon inhibition, or the immune response. A host resistance gene can therefore be an important component in determining the outcome of a particular virus infection. However, the severity of a virus-induced disease is the result of the interaction between host resistance genes, viral virulence genes, and the host defense system.
KeywordsWest Nile Virus Resistant Cell Inbred Mouse Susceptible Cell Yellow Fever Virus
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