Influence of Viruses on Cells of the Immune Response System
Viruses are ubiquitous infectious agents involved in both overt clinical as well as subclinical or undetectable interactions with eukaryotic cells. It is now widely recognized that various viruses of man and experimental animals may affect the immune response mechanisms to a variable degree (1,6,10). Immunologic hyporeactivity associated with many viral diseases, however, is not entirely a consequence of physical distress. Immunosuppression may be the first sign of illness induced by many viruses. It often reaches levels unjustified by the severity of the disease and, in some instances, persists much longer than other pathologic manifestations. Depending upon the type of virus causing the disease, the reduced ability of an individual to mount a normal immune response may or may not be accompanied by a fall in the preexisting levels of immunity, may be limited to cell-mediated immune responses or extend to humoral ones as well, may be directed selectively to certain types of antigens or may bring about a deficit in selected parameters of the immune response or classes of immunoglobulins.
KeywordsSpleen Cell Lymphoid Cell Leukemia Virus Infectious Mononucleosis Dengue Hemorrhagic Fever
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