In Vitro Macrophage Antimicrobial Activities and In Vivo Susceptibility to Leishmania Tropica Infection

  • Anne L. Haverly
  • Michael G. Pappas
  • Robin R. Henry
  • Carol A. Nacy
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


L. tropica, an obligate intracellular parasite, replicates in phagolysosomes of macrophages. Resistance to L. tropica infection may depend upon alteration of this intracellular environment (1,2). Soluble products of antigen- or mitogen-stimulated lymphocytes (lymphokines) induce enhanced macrophage antimicrobial activity against a number of intracellular organisms (3,4,5,6,7). These activated macrophages may be effector cells during resolution of L. tropica infections. In this study we analyzed the interaction of L. tropica and macrophages treated with lymphokines in vitro, and correlated these findings with susceptibility to L. tropica infection in vivo.


Mouse Strain Inbred Mouse Strain Microbicidal Activity Intracellular Killing Obligate Intracellular Parasite 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Anne L. Haverly
    • 1
  • Michael G. Pappas
    • 1
  • Robin R. Henry
    • 1
  • Carol A. Nacy
    • 1
  1. 1.Department of ImmunologyWalter Reed Army Institute of ResearchUSA

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