Antibody-Independent Mechanisms in the Development of Acquired Immunity to Malaria

  • William P. Weidanz
  • James L. Grun
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


The plasmodia are hemoprotozoan parasites which cause malaria in a variety of animal species, including man. Infection with these parasites stimulates acquired immune responses which are directed primarily against blood stages and, when successful, bring about a reduction in the number of circulating plasmodia and/or protect the host against reinfection with homologous parasites (1,2). While the actual mechanisms of resistance are ill-defined, it appears that immunity to malaria requires the participation of both T and B lymphocyte systems.


Nude Mouse Acute Infection Deficient Mouse Intact Mouse Challenge Infection 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • William P. Weidanz
    • 1
  • James L. Grun
    • 1
  1. 1.The Malaria Research Unit, Department of Microbiology and ImmunologyHahnemann Medical College and HospitalPhiladelphiaUSA

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