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Natural and Acquired Resistance to Trypanosoma Cruzi

  • Thomas M. Trischmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)

Abstract

Since the identification in 1909 of Trypanosoma cruzi as the causative agent of Chagas’ disease, a large body of literature has arisen relating to the nature of the disease. Two observations in particular initially stimulated my interest in the immunology of Chagas’ disease. The first was that the severity of the disease that occurs following the initial infection with T. cruzi (called the acute stage of the disease) can range from asymptomatic to lethal (1). This variation in what can be termed natural resistance may be the result of multiple genetic and environmental factors, but it is easy to imagine how differences in the immune responses made by individuals could be critical for influencing the ensuing course of the disease.

Keywords

Bone Marrow Cell Recombinant Inbred Trypanosoma Cruzi Congenic Strain Natural Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Thomas M. Trischmann
    • 1
  1. 1.Tropical Medicine CenterThe Johns Hopkins University School of Hygiene and Public HealthBaltimoreUSA

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