Parameters of Cellular Immunity in Acute and Chronic Rickettsia Tsutsugamushi Infections of Inbred Mice

  • T. R. Jerrells
  • J. V. Osterman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


The role of cell-mediated immunity (CMI) has been shown to be a major factor in acquired resistance to the obligate intracellular parasite R. tsutsugamushi. Specifically, it has been shown that immune animals possess spleen cells with the characteristics of thymus-derived lymphocytes (T-Cells) which confer protection against subsequent challenge when transferred to naive mice (9). The interaction of antigens with specifically sensitized T-cells can be demonstrated in vivo by a delayed-typed hypersensitivity (DTH) response (6), or in vitro by a specific antigen induced lymphocyte proliferative (LP) response (7).


Spleen Cell Keyhole Limpet Hemocyanin Scrub Typhus Lymphocyte Proliferative Response Lymphocyte Proliferation Assay 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • T. R. Jerrells
    • 1
  • J. V. Osterman
    • 1
  1. 1.Department of Rickettsial DiseasesWalter Reed Army Institute of ResearchUSA

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