Effect of Interferon Inducers and Purified Mouse Interferon on the Susceptibility of Mice to Infection with Listeria Monocytogenes

  • Sarah F. Grappel
  • Michael J. Polansky
  • Paul Actor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


Depression of cell-mediated immune reactions during viral infection has been a repeatedly confirmed phenomenon since the original observation of von Pirquet (20). Reports have included depression of tuberculin activity in man following viral infection or vaccination (2,3,12,16,19) as well as prolongation of allograft survival in virus-infected mice (14). Numerous investigations have indicated that virus-induced Type I interferons can modulate cell-mediated immune responses. These also include inhibition of the development of delayed-type hypersensitivity to tuberculin and sheep red blood cells (6,7) and prolongation of skin allograft survival in mice (13).


Confidence Limit Listeria Monocytogenes Mumps Virus Interferon Inducer Tuberculin Reaction 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Sarah F. Grappel
    • 1
  • Michael J. Polansky
    • 1
  • Paul Actor
    • 1
  1. 1.Smith Kline and French LaboratoriesPhiladelphiaUSA

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