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Cellular Mechanisms of Resistance to Listeria Monocytogenes

  • Emil Skamene
  • Patricia A. L. Kongshavn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)

Abstract

Listeria monocytogenes is a facultative intracellular bacterial parasite that can survive and multiply in mammalian macrophages. The infected host has at its disposal several lines of defense, each of which is mobilized in successive steps in the course of listeriosis. It has recently been demonstrated that the key mechanisms underlying successful anti-listerial resistance are genetically regulated. The availability of well-defined inbred mouse strains facilitated greatly the study of host-parasite interaction in listeriosis and it has become obvious that genetic control of host defense processes is simpler than originally anticipated. This review will deal mainly with the mechanisms of natural resistance to Listeria monocytogenes as uncovered in our laboratory using the genetic probe. The newer aspects of acquired resistance to this infection, a process which is now recognized as a classical example of cell-mediated immunity, will also be summarized briefly.

Keywords

Listeria Monocytogenes Susceptible Strain Natural Resistance Mononuclear Phagocyte System Dextran Sulphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Emil Skamene
    • 1
  • Patricia A. L. Kongshavn
    • 1
  1. 1.Montreal General Hospital Research Institute and Department of PhysiologyMcGill UniversityMontrealCanada

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