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Immunoregulatory Defects in Leprosy

  • Susan R. Watson
  • Ward E. Bullock
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)

Abstract

It was over one hundred years ago that the causative organism of human leprosy, Mycobacterium leprae was recognized by the Norwegian investigator, Armauer Hansen. Since that time our knowledge of this disease has advanced but little. M. leprae is an obligate intracellular parasite growing in the cells of the mononuclear phagocyte system with a special affinity for those tissue macrophages found in association with the skin, nerves, and lymphoreticular system. The organism has a very long generation time, estimated to be 10 to 15 days, which stands in comparison to M. tuberculosis that divides approximately every 20 hours, and coliform bacteria which divide every 20 to 30 minutes. To date the cultivation of M. leprae in vitro has proved elusive, thus hampering studies of the basic biology of the organism as well as the development of a potential vaccine against leprosy. For twenty years the principal method of studying the growth kinetics of the organism, the pharmacology of anti-leprous drugs, and the local pathology and immunity to the bacillus has been the mouse footpad model (1). However, in 1971, it was discovered that armadillos were susceptible to M. leprae and will support its multiplication in enormous numbers in vivo (2).

Keywords

Suppressor Cell Leprosy Patient Lepromatous Leprosy Plaque Form Cell Suppressor Cell Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Shepard, C.C. (1960). The experimental disease that follows the injection of human leprosy bacilli into footpads of mice. J. Exp. Med. 112:445.PubMedCrossRefGoogle Scholar
  2. 2.
    Kirchheimer, W.F. and Storrs, E.E. (1971). Attempts to establish the armadillo as a model for the study of leprosy. Int. J. Lepr. 39:693.Google Scholar
  3. 3.
    Ridley, D.S. and Jopling, W.H. (1966). Classification of leprosy according to immunity — A five group system. Int. J. Lepr. 34:255–273.Google Scholar
  4. 4.
    Ridley, D.S. (1974). Histological classification and the immunological spectrum of leprosy. Bull. Wld. Hlth. Org. 51:451.Google Scholar
  5. 5.
    Escobar-Gutierrez, A., et al. (1973). Distribution of the HLA-A system lymphocyte antigens in Mexicans II studies in atopics and lepers. Vox Sang. 25:151–155.CrossRefGoogle Scholar
  6. 6.
    Massoud, A., et al. (1978). A study of cell mediated immunity and histocompatibility antigens in leprosy patients in Iran. Int. J. Lepr. 46:149.Google Scholar
  7. 7.
    deVries, R.R.P., et al. (1980). HLA-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR types. Tissue Antigens. 16:294.CrossRefGoogle Scholar
  8. 8.
    Bullock, W.E. (1978). Leprosy: A model of immunological perturbation in chronic infection. J. Inf. Diseases. 137:341.CrossRefGoogle Scholar
  9. 9.
    Mackaness, G.B. (1971). Delayed hypersensitivity and the mechanism of cellular resistance to infection. Prog. Immunol. 1:413.Google Scholar
  10. 10.
    Closs, O. and Haugen, O.A. (1975). Experimental murine leprosy III early reaction to Mycobacterium lepraemurium in C3H and C57BL/6 mice. Acta. Path. Microbiol. Scand. Section A 83:51–58.Google Scholar
  11. 11.
    Beiquelman, B. (1967). Leprosy and genetics. Bull. Wld. Hlth. Org. 37:461.Google Scholar
  12. 12.
    Drutz, D.J. and Cline, M.J. (1974). Polymorphonuclear leukocyte and macrophage function in patients with leprosy. J. Clin. Invest. 53:380.PubMedCrossRefGoogle Scholar
  13. 13.
    Godal, T. and Rees, R.J.W. (1970). Fate of M. leprae in macrophages of patients with lepromatous or tuberculoid leprosy. Int. J. Lepr. 38:439.Google Scholar
  14. 14.
    Samuel, D.R., et al. (1973). Behavior of M. leprae in human macrophages in vitro. Infect. Immun. 8:446.PubMedGoogle Scholar
  15. 15.
    Convit, J., et al. (1974). Elimination of M. leprae subsequent to local in vivo activation of macrophages in lepromatous leprosy by other mycobacteria. Clin. Exp. Immunol. 17: 261.Google Scholar
  16. 16.
    Ptak, W., et al. (1970). Immune responses in mice with murine leprosy. Clin. Exp. Immunol. 6:117.PubMedGoogle Scholar
  17. 17.
    Bullock, W.E., et al. (1977). Impairment of cell mediated immune responses by infection with Mycobacterium leprae-murium. Infection and Immunity. 18:157.PubMedGoogle Scholar
  18. 18.
    Watson, S.R., et al. (1975). Defect of macrophage function in the antibody response to SRBC in systemic M. lepraemurium infection. Nature 256:206.PubMedCrossRefGoogle Scholar
  19. 19.
    Bullock, W.E., et al. (1978). The evolution of immunosuppressive cell populations in experimental mycobacterial infections. J. Immunol. 120:1709.PubMedGoogle Scholar
  20. 20.
    Gershon, R.K. (1974). T cell control of antibody production. Contemp. Top. Immunobiol. 3:1.PubMedGoogle Scholar
  21. 21.
    Thomas, Y., et al. (1980). Functional analysis of human T cell subsets defined by monoclonal antibodies. I collaborative T-T interactions in the immunoregulation of B cell differentiation. J. Immunol. 125:2402.PubMedGoogle Scholar
  22. 22.
    Ellner, J.J. (1978). Suppressor adherent cells in human tuberculosis. J. Immunol. 121:2573.PubMedGoogle Scholar
  23. 23.
    Hirschberg, H. (1978). The role of macrophages in the lymphoproliferative response to M. leprae in vitro. Clin. Exp. Immunol. 34:46.PubMedGoogle Scholar
  24. 24.
    Mehra, V., et al. (1979). Lepromin-induced suppressor cells in patients with leprosy. J. Immunol. 123:1813.PubMedGoogle Scholar
  25. 25.
    Mehra, V., et al. (1980). Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients. J. Immunol. 125:1183.PubMedGoogle Scholar
  26. 26.
    Nath, I. and Singh, R. (1980). The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy. Clin. Exp. Immunol. 41:406.PubMedGoogle Scholar
  27. 27.
    Touw, J., et al. (1980). Effect of M. leprae on lymphocyte proliferation: suppression of mitogen and antigen responses of human peripheral blood mononuclear cells. Clin. Exp. Immunol. 41:397.PubMedGoogle Scholar
  28. 28.
    Shou, et al. (1976). Suppressor activity after concanavalin A treatment of lymphocytes from normal donors. J. Exp. Med. 143:1100.PubMedCrossRefGoogle Scholar
  29. 29.
    Artz, R.R., et al. (1980). Decreased suppressor cell activity in disseminated granulomatous infections. Clin. Exp. Immunol. 41:343.PubMedGoogle Scholar
  30. 30.
    Nath, I., et al. (1979). Con A induced suppressor activity in human leprosy. J. Clin. Lab. Immunol. 2(4).Google Scholar
  31. 31.
    Fauci, A.S., et al. (1980). Activation of human B lymphocytes. XIV Cellular requirements, interactions and immunoregulation of pokeweed mitogen total-immuno-globulin producing plaque forming cells in peripheral blood. Cell. Immunol. 54:230.PubMedCrossRefGoogle Scholar
  32. 32.
    Dwyer, J.M., et al. (1973). Disturbance of the blood T-B lymphocyte ratio in lepromatous leprosy. N. Eng. J. Med. 288:1036.CrossRefGoogle Scholar
  33. 33.
    Reinherz, E.L. and Schlossman, S.F. (1980). The differentiation and function of human T lymphocytes. Cell 19:821.PubMedCrossRefGoogle Scholar
  34. 34.
    Bullock, W.E., et al. (1981). Hyperactivity of B lymphocyte function in lepromatous leprosy. Abst. 5066, Federation Proceedings. 40:1122.Google Scholar
  35. 35.
    Stobo, J.P. (1977). Immunosuppression in man: Suppression by macrophages can be mediated by interactions with regulatory T cells. J. Immunol. 119:918.PubMedGoogle Scholar
  36. 36.
    Nath, I., et al. (1980). Natural suppressor cells in human leprosy: The role of HLA-D identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses. Clin. Exp. Immunol. 42:203.PubMedGoogle Scholar
  37. 37.
    Bach, M.A., et al. (1981). Studies of T cell subsets and functions in leprosy. Clin. Exp. Immunol. 44:491.PubMedGoogle Scholar
  38. 38.
    Jerne, N.K. (1974). Towards a network theory of the immune system. Ann. Immunol. 125c:373.Google Scholar
  39. 39.
    Ramsier, H. and Lindenmann, J. (1972). Allotypic antibodies. Transplant. Rev. 10:57.Google Scholar
  40. 40.
    Rodkey, L.S. (1974). Studies of idiotypic antibodies: Production and characterization of autoanti-idiotypic antisera. J. Exp. Med. 139:712.PubMedCrossRefGoogle Scholar
  41. 41.
    Twomey, J.J., et al. (1978). A serum inhibitor of immune regulation in patients with systemic lupus erythematosus. J. Clin. Invest. 62:713.PubMedCrossRefGoogle Scholar
  42. 42.
    Sagawa, A. and Abdou, N.I. (1979). Suppressor-cell antibody in systemic lupus erythematous: possible mechanism for suppressor cell dysfunction. J. Clin. Invest. 63:536.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Susan R. Watson
    • 1
  • Ward E. Bullock
    • 1
  1. 1.The Division of Infectious Diseases, Department of MedicineUniversity of Cincinnati College of MedicineCincinnatiUSA

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