Cell Mediated Lysis of Lymphocytes Expressing Bacterial Antigens

  • J. A. Hank
  • P. M. Sondel
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


Two T cell subpopulations are involved in the primary in vitro response to allogeneic cells. The cytotoxic T lymphocyte (Tc) recognizes HLA-A, B, and C antigens. However, the Tc is activated to kill only after collaboration with a second sub-population, the helper T cell (Th), which responds proliferatively to HLA-D antigens (1). We have asked whether purified protein derivative (PPD) and soluble Candida antigens (CAN) can substitute for foreign HLA-D in providing a helper interaction to alloreactive Tc.


Proliferative Response Purify Protein Derivative Bacterial Antigen Allogeneic Cell Cell Surface Membrane 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. A. Hank
    • 1
  • P. M. Sondel
    • 1
  1. 1.University of WisconsinMadisonUSA

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