Host Response to Infection with Mycobacterium Bovis (BCG) in Mice: Genetic Study of Natural Resistance
Resistance of mice to several infectious agents has recently been shown to be under simple genetic control (reviewed in 1). Genetic differences in the response of outbred and inbred mice to infection with mycobacteria such as Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium lepraemurium have been noted for many years (2,3). We have recently reported that clear segregation of resistance and susceptibility to Mycobacterium bovis (BCG), exists among mice of inbred strains infected with a single intravenous dose of this bacillus (4). The present study deals with detailed genetic analysis of the trait of BCG resistance.
KeywordsInbred Strain Natural Resistance Mycobacterium Bovis Strain Distribution Pattern Sensitive Allele
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