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Host Defenses to Intracellular Pathogens pp 157–182Cite as

Cellular Mechanisms of Anti-Mycobacterial Immunity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 162))

Abstract

Tuberculosis is an ancient human disease (1), which continues to be an important public health problem, despite the development of effective vaccines and chemotherapeutic agents. Widespread use of chemotherapy has dramatically reduced worldwide mortality rates for this disease, but has not yet been able to eliminate it (2). Approximately 28,000 new cases of pulmonary tuberculosis were reported in the United States last year, with nearly 3,000 deaths directly attributable to this disease (3,4). This continued high rate of incidence some 30 years after the development of potentially effective control measures is both surprising and disturbing. However, it is only when the problem of controlling this disease in Asia, Africa, and Central America is examined, where overcrowding, malnutrition and inadequate health delivery services contribute still further to its continued persistence, that the true dimensions of this world public health problem begin to emerge (5).

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Authors and Affiliations

  1. Trudeau Institute, Inc., Saranac Lake, NY, USA

    Frank M. Collins

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  1. Frank M. Collins
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  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  2. Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania, USA

    Paul Actor

  3. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1983 Plenum Press, New York

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Collins, F.M. (1983). Cellular Mechanisms of Anti-Mycobacterial Immunity. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_16

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