Immunodepression in BALB/c Mice Infected with Leishmania Tropica
Leishmania tropica is an obligate intracellular parasite of macrophages which causes cutaneous leishmaniasis in man. Infections in BALB/c mice with this parasite are characterized by the development of large primary ulcers and multiple non-healing metastatic cutaneous lesions (1,2,3). To date, the immunological mechanisms responsible for the inability of BALB/c mice to resolve leishmanial infections are unknown; however, specific suppressor T cells responsible for regulating skin test responses to leishmanial antigens have been reported (3,4). In addition, BALB/c mice infected with L. tropica develop a non-specific immunodepression, as described in this report. This immunodepression is mediated by an adherent suppressor cell which suppresses mitogen and leishmanial antigen responses in a lymphocyte transformation assay.
KeywordsSpleen Cell Infected Mouse Suppressor Cell Cutaneous Leishmaniasis Stimulation Index
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