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Mediator Interactions Regulating Macrophage Secretion of Interleukin 1 and Interferon

  • Robert N. Moore
  • Patricia S. Steeg
  • Stephan E. Mergenhagen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)

Abstract

The mononuclear phagocyte system plays a critical role in host resistance to infection. The capacity of mononuclear phagocytes to deal with microorganisms appears, however, to be under regulatory control rather than static. Two mediators which appear to act in the process of macrophage differentiation and activation are interferon and colony-stimulating factor(s) (CSF). A substantial body of evidence indicates that interferon stimulates a variety of macrophage functions including phagocytosis, spreading, killing of microorganisms and tumor cells (1) and, recently, la-antigen expression (2). The effects of CSF are, however, less well known. The purpose of the present communication is to discuss recent findings which indicate that CSF as well as interferon can participate in the process of macrophage activation.

Keywords

Macrophage Activation Mononuclear Phagocyte System Interferon Production Plaque Reduction Assay Fibroblast Interferon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schultz, R.M., (1980). Lymphokine Rep. 1:63–97.Google Scholar
  2. 2.
    Steeg, P.S., Moore, R.N. and Oppenheim, J.J., (1981). Fed. Proc. Fed. Am. Soc. Exp. Biol. 40:771.Google Scholar
  3. 3.
    Burgess, A.W., Metcalf, D. and Watt, S.M. (1978). J. Supramol. Struct. 8:489–500.PubMedCrossRefGoogle Scholar
  4. 4.
    Trudgett, A., McNeill, T.A. and Killen, M. (1973). Infect. Immun. 8:450–455.PubMedGoogle Scholar
  5. 5.
    Bohme, D.H., Schneider, H.A. and Lee, J.M. (1959). J. Exp. Med. 110:9–24.PubMedCrossRefGoogle Scholar
  6. 6.
    Youngner, J.S. and Stinebring, W.R. (1965). Nature (London), 208:456.CrossRefGoogle Scholar
  7. 7.
    Mannel, D.N., Farrar, J.J. and Mergenhagen, S.E. (1980). J. Immunol. 124:1106–1110.PubMedGoogle Scholar
  8. 8.
    Weinberg, J.B., Chapman, H.A. and Hibbs, J.B. (1978). J. Immunol. 121:72–80.PubMedGoogle Scholar
  9. 9.
    Oppenheim, J.J., Moore, R., Gmelig-Meyling, F., Togawa, A., Wahl, S., Mathieson, B.J., Dougherty, S., and Carter, C. (1980). in “Macrophage Regulation of Immunity” (E.R. Unanue and A.S. Rosenthal, eds.) pp. 379–398, Academic Press, New York.Google Scholar
  10. 10.
    Kampschmidt, R.F. (1980). in “Microbiology-1980” (D. Schlessinger, ed.) pp. 150–153, ASM, Washington, D.C.Google Scholar
  11. 11.
    Murphy, P.A., Hanson, D.F., Simon, P.L., Willoughby, W.F. and Windle, B.E. (1980). in “Microbiology-1980” (D. Schlessinger, ed.) pp. 158–161, ASM, Washington, D.C.Google Scholar
  12. 12.
    Moore, R.N., Oppenheim, J.J., Farrar, J.J., Carter, C.S., Waheed, A. and Shadduck, R.K. (1980). J. Immunol. 125: 1302–1305.PubMedGoogle Scholar
  13. 13.
    Kurland, J.I., Peius, L.M., Ralph, P., Bockman, R.S., and Moore, M.A.S. (1979). Proc. Natl. Acad. Sci. U.S.A., 76:2326–2330.PubMedCrossRefGoogle Scholar
  14. 14.
    Moore, R.N., Vogel, S.N., Wahl, L.M. and Mergenhagen, S.E. (1980). in “Microbiology-1980” (D. Schlessinger, ed.), pp. 131–134, ASM, Washington, D.C.Google Scholar
  15. 15.
    Moore, R.N., Hoffeld, J.T., Farrar, J.J., Mergenhagen, S.E., Oppenheim, J.J. and Shadduck, R.K. (1981). Lymphokines, 3:119–148.Google Scholar
  16. 16.
    Farrar, J.J., Fuller-Farrar, J., Simon, P.L., Hilfiker, M.L., Stadler, B.M. and Farrar, W.L. (1980). J. Immunol. 125: 2555–2558.PubMedGoogle Scholar
  17. 17.
    Burgess, A.W., Metcalf, D., Russell, S.H.M. and Nicola, N.A. (1980). Biochem. J. 185:301–309.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Robert N. Moore
    • 1
  • Patricia S. Steeg
    • 2
  • Stephan E. Mergenhagen
    • 2
  1. 1.Department of MicrobiologyUniversity of TennesseeKnoxvilleUSA
  2. 2.Laboratory of Microbiology and ImmunologyNational Institute of Dental ResearchBethesdaUSA

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