Interferon and Host Defense Systems
Interferon (IFN) is defined as a protein(s) which exerts virus nonspecific, antiviral activity at least in homologous cells through cellular metabolic processes involving both RNA and protein synthesis (Reviewed in 1). Interferons are increasingly being recognized as having pleiotropic effects on cell function. These effects may be expressed in the form of anticellular, immunoregulatory, antitumor, and hormonal activities in addition to the well known antiviral activity. Interferon was discovered in 1957 by Isaacs and Lindenmann (2), and this discovery was based on its antiviral properties with a view toward understanding the nature of host defense against viral infections. In this overview we will attempt to convey the present day meaning of interferon in the context of its varied biological activities both at the cellular and molecular levels. Where appropriate, review articles will be cited, and these can serve as a source of original articles.
KeywordsSpleen Cell Suppressor Cell Antiviral Protein Host Defense System Suppressor Cell Activity
Unable to display preview. Download preview PDF.
- 1.Vilcek, J., Gresser, I., and Merigan, T.C. (eds.) (1980). Ann. New York Acad. Sci. 350:1–637.Google Scholar
- 3.Stewart, W.E., et al. (1980). J. Immunol. 125:2353.Google Scholar
- 17.Knight, E. (1980). Interferon 2 (I. Gresser, ed.), Academic Press 2:1.Google Scholar
- 24.Georgiades, J.A., et al. (1979). IRCS Med. Sci. 7:559.Google Scholar
- 25.Youngner, J.S. and Salvin, S.B. (1973). J. Immunol. 111:914.Google Scholar
- 29.Stanton, G.J., Johnson, H.M., and Baron, S. (1978). Path. Ann. 8:285.Google Scholar
- 32.Revel, M. (1979). Interferon 1 (I. Gresser, ed.), Academic Press 1:101.Google Scholar
- 34.Saneto, R., Holstun, S., and Johnson, H.M. (1980). IRCS Med. Sci. 8:921.Google Scholar
- 42.Johnson, H.M. and Baron, S. (1977). Pharmac. Ther. A 1:349.Google Scholar
- 43.Herberman, R.B. (ed.) (1980). Natural Cell-Mediated Immunity Against Tumors, Academic Press, New York.Google Scholar