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Theoretical and Experimental Aspects of Protein Folding

  • Harold A. Scheraga

Abstract

This article is based on the second and third of four lectures that I presented at the International Summer School of Biophysics. The first lecture, entitled “Recent developments in the theory of water, aqueous solutions and protein hydration,” has already been summarized in several review articles (Scheraga, 1979; Paterson et al., 1981; Némethy et al., 1981), and the fourth lecture, entitled “Enzyme — substrate interactions,” has likewise been summarized in two recent reviews (Pincus and Scheraga, 1981; Scheraga et al., 1982). In the two lectures constituting this article, we describe some of our theoretical and experimental work designed to gain an understanding of the interactions that lead to the observed conformational behavior of biological macromolecules, either as individual molecules or as complexes with other molecules. The theoretical aspects of the problem are dealt with first; this is then followed by a discussion of experimental studies on protein conformation.

Keywords

Disulfide Bond Antigenic Site Distance Constraint Folding Process Folding Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Harold A. Scheraga
    • 1
  1. 1.Baker Laboratory of ChemistryCornell UniversityIthacaUSA

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