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Beta-Adrenergic Stimulation of Adenylate Cyclase and Alpha-Adrenergic Inhibition of Adenylate Cyclase: GTP-Binding Proteins as Macromolecular Messengers

  • Lee E. Limbird
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)

Abstract

This review, which is a summary of an oral presentation made at the International Study Group for Research in Cardiac Metabolism, is a brief synopsis of work in our laboratory concerning the mechanism of hormonal regulation of adenylate cyclase. By its very nature, it refers almost entirely to our own work. However, since a number of laboratories have contributed to the field in ways at least as significant as our own, I recommend reading the reviews cited as references 4, 7 and 11 for a more comprehensive summary of the literature. The emphasis of this review is the role of GTP-binding proteins as important communicators between hormone-occupied receptors and the catalytic subunit of adenylate cyclase. The experimental work summarized emphasizes the extent to which one can determine the “intactness” receptor-effector coupling by focusing on receptor-agonist interactions, and modulation of these interactions by guanine nucleotides.

Keywords

Adenylate Cyclase Cholera Toxin Guanine Nucleotide Adenylate Cyclase Activity Large Molecular Size 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Lee E. Limbird
    • 1
  1. 1.Dept. of PharmacologyNashvilleUSA

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