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Allylamine Cardiotoxicity: Metabolism and Mechanism

  • Paul J. Boor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)

Abstract

Allylamine (CH2=CH-CH2NH2) is an unsaturated aliphatic amine which is used in the production of drugs, antiseptics, and plastics. Although many investigators have studied the potent and relatively specific cardiovascular toxicity of allylamine, the mechanism of its toxic action remains obscure.

Keywords

Monoamine Oxidase Myocardial Fibrosis Myocardial Necrosis Amine Oxidase Allyl Alcohol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Laiich, J.J.: Coronary artery hyalinosis in rats fed allylamine. Exp. Mol. Pathol. 10:14, 1969.CrossRefGoogle Scholar
  2. 2.
    Laiich, J.J., Allen, J.R. and Paik, W.C.W.: Myocardial fibrosis and smooth muscle cell hyperplasia in coronary arteries of allylamine-fed rats. Am. J. Pathol. 66:225, 1972.Google Scholar
  3. 3.
    Boor, P.J., Moslen, M.T. and Reynolds, E.S.: Allylamine cardiotoxicity. I. Sequence of pathologic events. Toxicol. Appl. Pharmacol. 50:581, 1979.PubMedCrossRefGoogle Scholar
  4. 4.
    Boor, P.J., Nelson, T.J. and Chieco, P.: Allylamine cardiotoxicity. II. Histopathology and histochemistry. Am. J. Pathol. 100:739, 1980.PubMedGoogle Scholar
  5. 5.
    Lalich, J.J. and Paik, W.C.W.: Influence of hydralazine consumption on allylamine-induced myocardial fibrosis and hypertrophy in rats. Exp. Mol. Pathol. 21:29, 1974.PubMedCrossRefGoogle Scholar
  6. 6.
    Will, J.A., Rowe, G.G., Olson, C. and Crumpton, C.W.: A chemically induced acute model of myocardial damage in intact calves. Res. Commun. Chem. Pathol. Pharmacol. 2:61, 1971.PubMedGoogle Scholar
  7. 7.
    Boor, P.J. and Ferrans, V.J.: Ultrastructural alterations in allylamine-induced cardiomyopathy. Lab. Invest., 47(1): (In Press), 1982.Google Scholar
  8. 8.
    Boor, P.J. and Nelson, T.J.: Allylamine cardiotoxocity: III. Protection by semicarbazide and in vivo derangements of monoamine oxidase. Toxicology 18:87–102, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Lewinsohn, R., Böhm, K.-H., Glover, V. and Sandler, M.: A benzylamine oxidase distinct from monoamine oxidase B -widespread distribution in man and rat. Biochem. Pharmacol. 27:1857, 1978PubMedCrossRefGoogle Scholar
  10. 10.
    Lyles, G.A. and Callingham, B.A.: Evidence for a clorgyline-resistant monoamine metabolizing activity in the rat heart. J. Pharm. Pharmac. 27:682, 1975.CrossRefGoogle Scholar
  11. 11.
    Bhansali, K.G., Hayes, B.E. and Clarke, D.E.: Benzylamine oxidase in rabbit lung. Fed. Proc. 41:1056, 1982.Google Scholar
  12. 12.
    Valiev, A.G.: Influence expected by some aliphatic amines on the monoamine oxidase activity in rats. Farmakol. Tosikol. (Moscow) 30:238, 1968.Google Scholar
  13. 13.
    Boor, P.J., Reynolds, E.S., Dammin, G.J. and Bailey, K.A.: Allylamine-induced myocardial damage: Protection by monoamine oxidase inhibitors. Fed. Proc. 36:397, 1977.Google Scholar
  14. 14.
    Serafini-Cessi, F.: Conversion of allyl alcohol into acrolein by rat liver. Biochem. J. 128:1103, 1962.Google Scholar
  15. 15.
    Nelson, T.J. and Boor, P.J.: Allylamine cardiotoxicity. IV. Metabolism to acrolein by cardiovascular tissues. Biochem. Pharmacol. 31:509–514, 1982.PubMedCrossRefGoogle Scholar
  16. 16.
    Luchi, R.J., Chahine, R.A. and Raizner, A.E.: Coronary Artery Spasm. Ann. Intern. Med., 91:441, 1979.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Paul J. Boor
    • 1
  1. 1.Department of Pathology, Chemical Pathology LaboratoryUniversity of Texas Medical BranchGalvestonUSA

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