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Cellular Immune Mechanisms in Coxsackievirus Group B, Type 3 Induced Myocarditis in Balb/C Mice

  • Sally A. Huber
  • Lilian P. Job
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)

Summary

Coxsackie B viruses are a common cause of viral myocarditis in humans. A murine model of the human disease has been developed using Coxsackievirus group B, type 3 and inbred Balb/c mice. Infection of T lymphocyte deficient mice does not result in significant myocarditis indicating the importance of T cells in this disease. The virus can be isolated from the hearts of T cell deficient and normal mice in equal concentrations. Virus elimination presumably is mediated by virus specific neutralizing antibody induced in both groups. T lymphocytes, natural killer cells and macrophage obtained from normal virus infected mice are all capable of lysing myofibers in vitro. Maximum lysis is obtained with the cytolytic T cells. When these cell populations or Coxsackievirus immune antibody were adoptively transferred into T lymphocyte deficient animals infected with the virus, only animals given T cells developed significant myocarditis.

Keywords

Spleen Cell Cytolytic Activity Plaque Form Unit Viral Myocarditis Coxsackie Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Sally A. Huber
    • 1
  • Lilian P. Job
    • 1
  1. 1.Department of PathologyUniversity of VermontBurlingtonUSA

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