The Role of Heart Binding Antibodies in Rheumatic Fever

  • John B. Zabriskie
  • Jacqueline E. Friedman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)


It is obvious to any student of cardiology that the heart may be injured in a number of ways only some of which are immunologically mediated. However as our knowledge of cardiac pathologic mechanisms increases, it is this author’s opinion that immunological mechanisms will play a much greater role in cardiac pathology than has hitherto been suspected. On this note I would like to review with you at least one example where a microbial-host immunological interaction appears to play a dominant role in causing cardiac damage. Hopefully further knowledge of this disease state may provide information concerning a number of myocardial diseases the etiology of which is still unknown.


Rheumatic Fever Acute Rheumatic Fever Scarlet Fever Bovine Heart Protein Moiety 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John B. Zabriskie
    • 1
  • Jacqueline E. Friedman
    • 1
  1. 1.Rockefeller UniversityNew YorkUSA

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