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Lipid Peroxidation and Acute Myocardial Ischemia

  • Parinam S. Rao
  • Hiltrud S. Mueller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)

Abstract

Lipid peroxides (LP) and free radicals (FR) have recently been identified by us as metabolic intermediates during acute myocardial ischemia. The mechanism of lipid peroxidation is not clearly understood. We hypothesize: 1) FR production increases during ischemia due to alteration in the redox state of the mitochondria and due to interaction between metabolites and O2; 2) FR foster increased formation of LP with a concomitant decrease in protective antioxidants such as glutathione peroxidase (GP) and ascorbic acid (ASC). To test this hypothesis, we first studied animal models, rat and dog. In the rat, 48 hrs post coronary occlusion (CO), the lipid peroxide content in the infarcted left ventricular tissue (LV) measured as its product malondialdehyde (MDA) increased from 0.31 to 0.58 nm/ mg P (p<.001), an increase of 87% while GP decreased from 62 to 21 nm/min/mg P (p<.001). Superoxide dismutase contents decreased from 81 to 63 µg/g (p<.001). The polyunsaturated fatty acid (PUFA) contents diminished significantly (arachidonic acid from 19 to 16%, p<.001). In the dog, sequential transcardiac changes in blood showed very early increase of both FR as studied by electron spin resonance spectrometry in lyophilized samples and catecholamines (norepinephrine, NE, and epinephrine, E).

Keywords

Ascorbic Acid Lipid Peroxide Electron Spin Resonance Glutathione Peroxidase Coronary Sinus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Parinam S. Rao
    • 1
  • Hiltrud S. Mueller
    • 1
  1. 1.Department of MedicineMontefiore Hospital and Albert Einstein College of MedicineBronxUSA

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