The Effect of 5-Hydroxytryptamine and Arterial Blood Withdrawal on Cerebral Microcirculation in the Cat, Arterial Permeability in the Rabbit

  • R. J. Bing
  • Bing-Lo Chang
  • G. Santillan
  • M. Sato
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)


Studies dealing with the effect of 5-HT on cerebral cortical microcirculation of cats and on permeability of femoral arteries to RISA of rabbits are presented. The effect of 5-HT on cerebral cortical microcirculation was compared to that of arterial blood withdrawal and blood reinfusion. The effect of topical administratior of 5-HT was also studied. Cortical microcirculation was observed by transillumination using a microtransilluminator. Motion pictures were taken at a speed of 400 frames/sec. and a magnification of 3000X. Permeability was investigated using arterial RISA uptake in vessels perfused in vitro, with continuous recording of perfusion pressure.


Cerebral Blood Flow Vascular Permeability Perfusion Pressure Systemic Blood Pressure Reactive Hyperemia 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • R. J. Bing
    • 1
  • Bing-Lo Chang
    • 1
  • G. Santillan
    • 1
  • M. Sato
    • 1
  1. 1.Department of Experimental Cardiology, Huntington Medical Research InstitutesThe Huntington Memorial Hospital, and the California Institute of TechnologyPasadenaUSA

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