Factors Determining Virgin and Postantigenic Repertoires of B Cell Population and its Subsets
The repertoire of specifities (different Ig FV pieces) that a population of B lymphocytes can produce is large but its size depends on what meaning is given to the word. Two meanings are important for this discussion (Table 1). One (the virgin repertoire) is the collection of FV pieces in antigen-free individuals. The other repertoire includes all FV structures that individuals of a certain genotype (say the BALB/c mouse) can produce when immunized with all possible antigens (the potential postantigenic repertoire). When it is discussed whether known mechanisms of diversity-generation are sufficient to explain the observed variability this potential postantigenic repertoire is often in the minds of the discussers.
KeywordsNewborn Mouse Cell Repertoire Polysaccharide Conjugate IgG3 Cell Immunological Unresponsiveness
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