The Degree of Clonal Elimination in Immunological Tolerance and Regulation of Heavy Chain Class Switches

  • Göran Möller
  • Susanne Bergstedt-Lindqvist
  • Carmen Fernandez
  • Eva Severinson
Part of the Nobel Foundation Symposia Published by Plenum book series (NOFS, volume 55)


Most concepts of the mechanism of lymphocyte activation and of tolerance induction are based on the interaction between antigen and the immunoglobulin (Ig) receptors. It is of importance, therefore, to study whether the entire clone is affected during the immune response or in tolerance induction, since the only common property of the clone is that all the cells have the same Ig receptor. It is already clear than an immune response does not involve all B cells in a clone. One example is given by Paul et al. in this symposium, when he shows that the Lyb-5 markers determine the ability to respond rather than the Ig receptors. However, it is less clear in tolerance induction and at least one theory of tolerance induction1 actually predicts that tolerance results in clonal deletion and is the consequence of antigen interaction with the Ig receptors in the absence of a second signal.


Tolerance Induction C57BL Mouse Immunological Tolerance Immunoglobulin Receptor Heavy Chain Class 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bretscher, P.A. and Cohn, M. Science 169: 1042, 1970.PubMedCrossRefGoogle Scholar
  2. 2.
    Andersson, J., Sjöberg, O. and Möller, G. Transpl. Rev. 11: 31, 1972.Google Scholar
  3. 3.
    Fernandez, C., Lieberman, R and Möller, G. Scand. J. Immunol. 10: 77, 1979PubMedCrossRefGoogle Scholar
  4. 4.
    Fernandez, C. and Möller, G. J. Exp. Med. 147: 645, 1978.CrossRefGoogle Scholar
  5. 5.
    Howard, J.G., Vicari, G. and Courtenay, B.M. Immunol. 29: 585, 1975Google Scholar
  6. 6.
    Howard, J.G., Vicari, G. and Courtenay, B.M. Immunol. 14: 253, 1975Google Scholar
  7. 7.
    Fernandez, C. and Möller, G. Scand. J. Immunol. 7: 137, 1978.PubMedCrossRefGoogle Scholar
  8. 8.
    Weigle, W.O. J. Exp. Med. 116: 913, 1962.CrossRefGoogle Scholar
  9. 9.
    Weigle, W.O., Chiller, J.M. and Habicht, G.S. Transpl. Rev. 8: 3, 1972.Google Scholar
  10. 10.
    Möller, G. and Fernandez, C. Scand. J. Immunol. 8: 29, 1978.PubMedCrossRefGoogle Scholar
  11. 11.
    Fernandez, C. and Möller, G. J. Exp. Med. 146: 308, 1977.CrossRefGoogle Scholar
  12. 12.
    Fernandez, C. and Möller, G. Scand. J. Immunol. 11: 53, 1980.PubMedCrossRefGoogle Scholar
  13. 13.
    Martinez, A., Coutinho, A. and Augustin A.A. Eur. J. Immunol. 10: 698, 1980CrossRefGoogle Scholar
  14. 14.
    Augustin, A.A. and Coutinho, A. J. Exp. Med. 151: 587, 1980.CrossRefGoogle Scholar
  15. 15.
    Kearny, J.F. In “Developments in Immunology.” Eds. M. Cooper, I. Sher and E.S. Vitetta. Elsevier-North Holland Inc. Amsterdam, p. 77, 1979.Google Scholar
  16. 16.
    Severinson-Gronowicz, E., Doss, C., Assisi, F., Vitetta, E.S., Coffman, R.L. and Strober, S. J. Immunol. 123: 2049, 1979.Google Scholar
  17. 17.
    Bergstedt-Lindqvist, S., Fernandez, C. and Severinson, E. Scand. J. Immunol. 15: 439, 1982.CrossRefGoogle Scholar
  18. 18.
    Rosenberg, Y.J. and Chiller, J.M. J. Exp. Med. 150: 517, 1979.CrossRefGoogle Scholar
  19. 19.
    Perlmutter, R.M., Hansburg, D., Brites, D.E., Nicolotti, R.A. and Davie, J.M. J. Immunol. 121: 566, 1978.PubMedGoogle Scholar
  20. 20.
    Isakson, P.C., Puré, E., Vitetta, E.S. and Krammer, P.H. J. Exp. Med. 155: 734, 1982.CrossRefGoogle Scholar
  21. 21.
    Bergstedt-Lindqvist, S. and Severinson, E. Submitted for publication 1982.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Göran Möller
    • 1
  • Susanne Bergstedt-Lindqvist
    • 1
  • Carmen Fernandez
    • 1
  • Eva Severinson
    • 1
  1. 1.Department of ImmunobiologyKarolinska Institute WallenberglaboratoryStockholmSweden

Personalised recommendations