The Degree of Clonal Elimination in Immunological Tolerance and Regulation of Heavy Chain Class Switches
Most concepts of the mechanism of lymphocyte activation and of tolerance induction are based on the interaction between antigen and the immunoglobulin (Ig) receptors. It is of importance, therefore, to study whether the entire clone is affected during the immune response or in tolerance induction, since the only common property of the clone is that all the cells have the same Ig receptor. It is already clear than an immune response does not involve all B cells in a clone. One example is given by Paul et al. in this symposium, when he shows that the Lyb-5 markers determine the ability to respond rather than the Ig receptors. However, it is less clear in tolerance induction and at least one theory of tolerance induction1 actually predicts that tolerance results in clonal deletion and is the consequence of antigen interaction with the Ig receptors in the absence of a second signal.
KeywordsTolerance Induction C57BL Mouse Immunological Tolerance Immunoglobulin Receptor Heavy Chain Class
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