T-Cell Growth Factor, a Lymphocytotrophic Hormone
Despite an intensive effort over the past twenty years, our understanding of the process by which the immune response is regulated remains rudimentary. In part, our difficulties in this area have related to the morphological homogeneity but functional heterogeneity of the cells responsible for the immune reaction. The dissection of the mechanisms that underlie the regulatory control of the immune response has been facilitated, however, by the development of cell culture systems that can be made to generate measurable immune reactions, and thus mimic immune responses as they are thought to occur in vivo. As a result, it has become apparent that the differentiation of lymphocytes to become functionally competent immunocytes, is dependent upon a complex intercellular communication system that involves not only different classes and subclasses of lymphocytes, but macrophages as well. Consequently, considerable attention has focused on the roles played by each cell type, and the mechanisms operative.
KeywordsHuman Peripheral Blood Lymphocyte Polypeptide Hormone Isolate Plasma Membrane Purify Plasma Membrane Secondary Mediator
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