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Immunological Surveillance: T Cell Repertoire and the Biological Function of MHC Antigens

  • Peter C. Doherty
Part of the Nobel Foundation Symposia Published by Plenum book series (NOFS, volume 55)

Abstract

Ten years ago we had no clear idea of the biological role of the major histocompatibility complex (MHC), though many people were trying to deal with the issue intellectually.1–4 The phenomenon of alloreactivity dominated both experiments and concepts. Considerable effort had been put into the study of graft rejection and the strong transplantation antigens. Could it be that these extremely potent immune responses, and the glycoproteins at which they were directed, had no physiological function other than the elimination of transplanted tissues? Was alloreactivity a phylogenetic remnant of the need to avoid mutual parasitism in primitive life forms, now used in complex vertebrates to limit the emergence of spontaneous tumors? Such thinking led to Burnet’s formulation of the immunological surveillance concept.5

Keywords

Major Histocompatibility Complex Cell Repertoire Immune Response Gene Major Histocompatibility Complex Antigen Major Histocompatibility Complex Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Peter C. Doherty
    • 1
  1. 1.Department of Experimental PathologyThe John Curtin School of Medical ResearchCanberraAustralia

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