Molecular Analyses of MHC Antigens

  • O. Kämpe
  • D. Larhammar
  • K. Wiman
  • L. Schenning
  • L. Claesson
  • K. Gustafsson
  • S. Pääbo
  • J. J. Hyldig-Nielsen
  • L. Rask
  • P. A. Peterson
Part of the Nobel Foundation Symposia Published by Plenum book series (NOFS, volume 55)

Abstract

The major histocompatibility complex (MHC) has an essential role in the immune system. In a direct manner some of the MHC antigens, the class I molecules, seem to be involved in combatting virus-infections inasmuch as MHC antigens on virus-infected cells are part of the target for T-killer cells. Such T-cell killing is generally restricted to the virus and one or more of the class I molecules of the infected cell (see ref. 1). Whether one T-cell receptor jointly recognizes a virus product in association with a class I antigen or whether separate T-cell receptors independently recognize the virus product and the class I antigen, respectively, is not yet resolved (for a recent review see ref. 2). In this paper we will discuss our approach to analyze this issue.

Keywords

Migration Carbohydrate Propionate Cysteine Carboxyl 

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • O. Kämpe
    • 1
  • D. Larhammar
    • 1
  • K. Wiman
    • 1
  • L. Schenning
    • 1
  • L. Claesson
    • 1
  • K. Gustafsson
    • 1
  • S. Pääbo
    • 1
  • J. J. Hyldig-Nielsen
    • 1
  • L. Rask
    • 1
  • P. A. Peterson
    • 1
  1. 1.Dept. of Cell ResearchThe Wallenberg LaboratoryUppsalaSweden

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