The Formation of Antibody Variable Region Genes
The solution of the problem of how immunoglobulin genes produce antibody molecules is the result of extraordinary developments in the fields of immunology and molecular biology. The immunochemists, of course, discovered the interesting features of the structure of antibody molecules and proposed a variety models to account for the structural and organizational features of this remarkable class of proteins. The molecular biologists, on the other hand, set out to develop the genetic approaches that would—in the end—put these theories to the test. Six or seven years ago neither of these groups could have anticipated the spectacular success that the development of recombinant DNA technology has made possible. Many of the questions raised by immunologists are now answered in concrete terms. We know how immunoglobulin genes are encoded in germline DNA and how this structure is altered in antibody producing cells. We know that several powerful mechanisms exist to shuffle bits of DNA and RNA in somatic cells and we know how these mechanisms act to create diversity. We also suspect that we are viewing mechanisms that have significance beyond the immune system itself.
KeywordsHeavy Chain Versus Region Human Immunoglobulin Immunoglobulin Gene Light Chain Gene
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