Insect Growth Regulators: Resistance and The Future

  • Thomas C. Sparks
  • Bruce D. Hammock


In 1967 Carroll Williams summarized several years of campaigning for a revolution in pesticide chemistry with the publication of an article entitled “Third Generation Pesticides.” His lectures on the golden oil of Ceovopia helped to inspire the identification of the first juvenile hormone (JH) structure (Roller et al., 1976) as well as the synthesis of potent and relatively inexpensive JH mimics (Law et al., 1966; Bowers, 1968, 1969). Among the many potential advantages of the third generation pesticides was one predicted in the statement, “Now insect hormones promise to provide insecticides that are not only more specific but also proof against the evolution of resistance” (Williams, 1967). This statement was seriously questioned (Ellis, 1968; Schneiderman, 1971, 1972), and shortly thereafter it was shown to be invalid by the publication of two papers demonstrating that strains resistant (R) to pesticides could be cross-resistant to JHs (Dyte, 1972) and their mimics (Cerf and Georghiou, 1972).


Juvenile Hormone Cross Resistance Insect Growth Regulator Boll Weevil Juvenile Hormone Analogue 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Thomas C. Sparks
    • 1
  • Bruce D. Hammock
    • 1
  1. 1.Department of Entomology, Louisiana Agricultural Experiment StationLouisiana State UniversityBaton RougeUSA

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