Resistance to Insecticides Due to Reduced Sensitivity of the Nervous System

  • Toshio Narahashi


In order to understand the mechanism underlying the physiological resistance of an insect to an insecticide, we must know how the insecticide exerts its toxic action. Among a number of processes involved, three factors have been regarded as playing the most important roles in insect resistance to insecticides: penetration of insecticides through the cuticle, detoxication, and sensitivity of the target site. Penetration and detoxication mechanisms are discussed in other papers of this volume.


Sodium Channel Sodium Current Giant Axon Squid Giant Axon Nerve Membrane 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Toshio Narahashi
    • 1
  1. 1.Department of PharmacologyNorthwestern University Medical SchoolChicagoUSA

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