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Unconventional Catalytic Properties of Conventional Enzymes: Applications in Organic Chemistry

  • Alexander M. Klibanov
Part of the Basic Life Sciences book series

Abstract

The major objective of this paper is to stress that enzymes, in addition to their “normal” reactions (reflected in their names), often can catalyze other, sometimes quite different processes. The latter, although unimportant for the enzyme-producing organism, can be very valuable for biotechnological applications. The examples of “unnatural” catalytic activities of common enzymes that are considered, taken from the author’s recent studies, include: (i) reduction of aromatic compounds catalyzed by glucose oxidase; (ii) prochiral and enantiomeric stereospecificity of galactose oxidase in the oxidation of non-sugar, three-carbon alcohols; (iii) selective hydroxylation of aromatic compounds catalyzed by peroxidase; (iv) geometrically and positionally specific oxidation of aromatic aldehydes catalyzed by xanthine oxidase.

It is pointed out that along with conventional bacterial screening, a “chemical screening”, i.e., the search for new, unconventional catalytic activities for known enzymes, can be beneficial.

Keywords

Xanthine Oxidase Glucose Oxidase Trans Isomer Aromatic Aldehyde Ascorbate Oxidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Alexander M. Klibanov
    • 1
  1. 1.Laboratory of Applied Biochemistry Department of Nutrition and Food ScienceMassachusetts Institute of TechnologyCambridgeUSA

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