Design and Synthesis of Optically-Pure Compounds Using Microbial Systems

  • Charles J. Sih
  • Ching-Shih Chen
  • Gary Girdaukas
  • Bing-Nan Zhou
Part of the Basic Life Sciences book series


As the useful biological activities of most therapeutic agents are associated with only one enantiomer, the preparation of optically-pure compounds continues to be a major contemporary problem of synthetic organic chemistry. Because conventional chemical transformations generally give statistical mixtures of optical enantiomers, it is necessary to remove the unwanted antipode at the end of the reaction sequence by resolution using an asymmetric agent, which is often a natural product.


Enantiomeric Excess Total Synthesis Optical Purity Kinetic Resolution Microbial System 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Charles J. Sih
    • 1
  • Ching-Shih Chen
    • 1
  • Gary Girdaukas
    • 1
  • Bing-Nan Zhou
    • 1
  1. 1.School of PharmacyUniversity of WisconsinMadisonUSA

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