Hemostasis and Atherosclerosis

  • Fedor Bachmann
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 58)


This review, although not intending to call into question the important role of hyperlipidemia and especially of LDL-cholesterol in the pathogenesis of atherosclerosis, aims to familiarize the reader with other etiologic factors of atherosclerosis. Recent experimental work clearly shows that under certain conditions, the development of atherosclerotic plaques can be inhibited despite hypercholesteremia. Kramsch et al. fed rabbits an atherogenic diet with and without increasing doses of lanthanum chloride, a potent calcium antagonist. Whereas all animals exhibited severe cholesteremia of 20 to 25 g/l, extensive atherosclerotic lesions comprising 64% of the aortic surface area developed only in those given the atherogenic diet without lanthanum’. There was a progressive reduction of aortic surface area involvement with increasing dosage of lanthanum to 16% (20 mg LaC13/kg/d) and to less than 3% (40 mg LaC13/kg/d). Fuster et al. observed that the aortas of pigs afflicted with homozygous von Willebrand’s disease did not exhibit multiple atheromatous plaques whereas those of normal pigs did2. These authors undertook a prospective trial on the role of von Willebrand factor (the multimeric blood coagulation Factor VIII complex) in the pathogenesis of atherosclerosis. They fed a 2% cholesterol diet to 11 control pigs and to 7 pigs with von Willebrand’s disease. All of the controls developed atherosclerotic plaques in the aorta and in 9, at least 13% of the entire surface was involved. In contrast, 4 of the pigs with von Willebrand’s disease did not develop such lesions, 2 had lesions affecting 6 and 7% of the aortic surface and only one had 13% of the aortic surface involved. In pigs with von Willebrand disease, the extent of endothelial damage was equally severe as in the controls, and there was extensive nonproliferative, nonatherosclerotic intimai fat infiltration.


Fibrinolytic Activity Platelet Reactivity Platelet Factor Atherogenic Diet Type Versus Collagen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



(giga) = 109


platelet derived grow factor


platelet factor 4


smooth muscle cells


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Fedor Bachmann
    • 1
  1. 1.Hematology Division and Thrombosis Research LaboratoryUniversity of Lausanne, Medical School, CHUVLausanneSwitzerland

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