Functional Aspects of Atherogenesis

  • Kenneth W. Walton
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 58)


There is still a tendency to look upon arteries as impermeable tubes and upon ‘arterial pollution’ (atherosclerosis) as either arising from degeneration of intrinsic components of the arterial wall (1) or as due to the passive accumulation of a kind of ’sludge’ on the inner surface (thrombi deposited on the intima) which subsequently undergoes breakdown and incorporation into the wall (2). However, modern physiological and pathological evidence suggests that, instead, arteries should be considered as composed of tubes of a living and reactive gel through which blood is pumped at a pressure such that there is normally an ultrafiltration or permeation of whole plasma through the wall with its removal or drainage from the outer coats by lymphatics (3).


Arterial Wall Atherosclerotic Lesion Functional Aspect Ground Substance Arterial Lesion 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Kenneth W. Walton
    • 1
  1. 1.Department of Investigative Pathology Medical SchoolUniversity of BirminghamBirmingham 15England

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