Atherosclerosis: Its Origins and Development in Man

  • G. A. Gresham
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 58)


Arterial disease has been described in Egyptian mummies of the second century B.C.1 However these lesions are not atherosclerotic but consisted of the medial calcification of Monckeberg’s sclerosis which is well developed in the long arteries of the limbs. Anatomical descriptions of atherosclerosis were first made in the eighteenth and nineteenth centuries but the clinical features of coronary artery disease did not become manifest until the start of the twentieth century.


Coronary Artery Smooth Muscle Cell Aortic Calcification Intimal Thickening Fatty Streak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    M. A. Ruffer, On arterial lesions found in Egyptian mummies (1580 B.C. — 525 A.D.), J. Pathol. Bacterial. 15: 453 (1911).CrossRefGoogle Scholar
  2. 2.
    Kang-Jey Ho, K. Biss, B. Mikkelson, L. A. Lewis and C. B. Taylor, The Masai of East Africa: some unique biological characteristics, Arch. Path. 91: 387 (1971).PubMedGoogle Scholar
  3. 3.
    D. J. De Sa, Coronary arterial lesions and myocardial necrosis in stillbirths and infants, Arch. Dis. Child. 54: 918 (1979).PubMedCrossRefGoogle Scholar
  4. 4.
    M. J. Reisman, Atherosclerosis and pediatrics, J. Paediatrics 66: 1 (1965).CrossRefGoogle Scholar
  5. 5.
    L. Jores, Arterien, in “Handbuch der speziellen pathologischen Anatomie und histologie Band II Herz und Gefasse.” F. Henke and O. Lubarsch, eds. Publisher, Julius Springer Berlin (1924).Google Scholar
  6. 6.
    H. Z. Movat, R. H. More and M. D. Haust, The diffuse intimai thickening of the human aorta with ageing, Amer. J. Pathol. 34: 1023 (1958).Google Scholar
  7. 7.
    H. C. Stary and J. P. Strong, Coronary artery fine structure in rhesus monkeys: non atherosclerotic intimai thickening, in: “Primates in Medicine”, Publisher, Karger Basel (1976).Google Scholar
  8. 8.
    W. Dock, Predilection of atherosclerosis for coronary arteries, J. Amer. Med. Assoc. 131: 875, (1946).CrossRefGoogle Scholar
  9. 9.
    H. M. Neufeld, C. A. Wagenvoort and J. E. Edwards, Coronary arteries in fetuses, infants, juveniles and young adults, Lab. Invest. 11: 837 (1962).PubMedGoogle Scholar
  10. 10.
    E. H. Oppenheimer and J. T. Esterly, Cardiac lesions in hypertensive infants and children, Arch. Pathol. 84: 318 (1967).PubMedGoogle Scholar
  11. 11.
    D. Velican and C. Velican, Comparative study on age-related changes and atherosclerotic involvement of the coronary arteries of male and female subjects up to 40 years of age, 38: 39 (1981).Google Scholar
  12. 12.
    C. Velican and D. Velican, Coronary intimai necrosis occurring as an early stage of atherosclerotic involvement, Atherosclerosis 39: 479 (1981).PubMedCrossRefGoogle Scholar
  13. 13.
    G. Gabiani, G. B. Ryan and G. Matno, Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction, Experiential 27: 549 (1971).CrossRefGoogle Scholar
  14. 14.
    D. Velican and C. Velican, Atherosclerotic involvement of the coronary arteries of adolescents and young adults, Atherosclerosis 36: 449 (1980).PubMedCrossRefGoogle Scholar
  15. 15.
    H. C. McGill, Jr., in: “The Geographical Pathology of Atherosclerosis”, H. C. McGill, ed., Publisher, Williams and Wilkins, Baltimore, Maryland (1968).Google Scholar
  16. 16.
    G. A. Gresham, Is atheroma a reversible lesion? Atherosclerosis 23: 379 (1976).PubMedCrossRefGoogle Scholar
  17. 17.
    T. A. Pearson, K. Solez, J. M. Dillman and R. H. Heptinstall, Evidence for two populations of fatty streaks with different roles in the atherogenic process, Lancet II: 496 (1980).CrossRefGoogle Scholar
  18. 18.
    H. C. McGill Jr. and J. P. Strong, The geographic pathology of atherosclerosis, Ann. New York Acad. of Sci. 149: 2 (1968).Google Scholar
  19. 19.
    J. P. Strong, C. Restrepo and M. A. Guzman, Coronary and aortic atherosclerosis in New Orleans, Lab. Invest. 39: 364 (1968).Google Scholar
  20. 20.
    J. P. Strong and M. A. Guzman, Decrease in coronary atherosclerosis in New Orleans, Lab. Invest. 43: 279 (1980).Google Scholar
  21. 21.
    C. C. Chidi and R. G. DePalma, Collagen formation by transformed smooth muscle cells after arterial injury, Surd. Gvnec. and Obstet,. 152: 8 (1981).Google Scholar
  22. 22.
    C. W. M. Adams, O. B. Bayliss, M. Z. M. Ibrahim, M. W. Webster Jr., Phospholipids in atherosclerosis the modification of the cholesterol granuloma by phospholipid, J. Pathol. Bacteriol. 86: 431 (1963).PubMedCrossRefGoogle Scholar
  23. 23.
    H. Kaunitz, Cholesterol and repair processes in arteriosclerosis, Lipids 13: 373 (1978).PubMedCrossRefGoogle Scholar
  24. 24.
    M. D. Haust, R. H. More and H. Z. Movat, The mechanism of fibrosis in arteriosclerosis Amer. J. Pathol. XXXV: 265 (1959).Google Scholar
  25. 25.
    P. Constantinides, Plaque fissure in human coronary thrombosis, J. Atherosclerosis Res. 6: 1 (1966).CrossRefGoogle Scholar
  26. 26.
    H. R. Hellstrom, Evidence in favour of the vaso-spastic cause of coronary artery thrombosis, Amer. Heart J. 97: 449 (1979).PubMedCrossRefGoogle Scholar
  27. 27.
    M. B. Gardner and D. H. Blankenhorn, Aortic medial calcification, Arch. Pathol. 85: 397 (1968).PubMedGoogle Scholar
  28. 28.
    D. A. Eggen, J. P. Strong and H. C. McGill, Calcification in the abdominal aorta, Arch. Pathol. 78: 575 (1964).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • G. A. Gresham
    • 1
  1. 1.University of CambridgeUK

Personalised recommendations