Diabetes: Is it a Risk Factor for Atherosclerosis?

  • M. Mancini
  • G. Riccardi
  • A. Rivellese
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 58)


Diabetic patients are more prone to develop atherosclerosis and its complications than non diabetics. This is demonstrated by several clinico-pathological and epidemiological observations (1–3). One of the most accurate of these is the Framingham study which clearly demonstrates that the average annual incidence of vascular disease is higher in diabetics at all age groups, in both sexes and in all main arterial districts (4).


Blood Glucose Diabetic Patient High Fibre Diet Average Annual Incidence Inclination Time 
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  1. 1.
    L.D. Ostrander, J. jr. Francis, N.S. Hagner, M.D. Mjelsberg, and F.V. Epstein, The relationship of cardiovascular disease to hyperglycemia, Ann. Intern. Med., 62: 1188 (1965).PubMedGoogle Scholar
  2. 2.
    M.J. Garcia, P.M. Mc Namara, and R. Gordon, Morbidity and mortality in diabetics in the Framingham population, sixteen years follow up study, Diabetes, 23: 105 (1974).PubMedGoogle Scholar
  3. 3.
    J.M.B. Bloodworth, Vascular disease and Diabetes Mellitus in: ‘Diabetes Mellitus’, Diagnosis and treatment, vol71, Hamwi, G.J., Danowski, T.S. (eds.), American Diabetes Association, New York (1967).Google Scholar
  4. 4.
    W.B. Kannel, and D.L. McGee, Diabetes and glucose tolerance as risk factors for cardiovascular disease: The Framingham study, Diabetes Care, 2: 120 (1979).PubMedCrossRefGoogle Scholar
  5. 5.
    H. Keen, and R.J. Jarrett, The WHO multinational study of vascular disease in Diabetes: 2. Macrovascular Disease prevalence, Diabetes Care, 2: 187 (1979).PubMedCrossRefGoogle Scholar
  6. 6.
    L.D. Ostrander, D.E. Lamhpiear, W.J. Carmen, and G.W. Williams, Blood glucose and risk of coronary heart disease, Arteriosclerosis, 33 (1981).Google Scholar
  7. 7.
    K.W. Beach, J.D. Brunzell, L.L. Conquest, and D.E. Strandness, The correlation of arteriosclerosis obliterans with lipoprotein in insulin-dependant and non insulin-dependent diabetes, Diabetes, 28: 836 (1979).PubMedGoogle Scholar
  8. 8.
    V. Janka, E. Standl, and H. Mehnert, Peripheral vascular disease in Diabetes Mellitus and its relation to cardiovascular risk factors: screening with the Doppler ultrasonic Technique, Diabetes Care, 3: 207 (1980).PubMedCrossRefGoogle Scholar
  9. 9.
    J.H. Fuller, M.J. Shipley, G. Rose, R.J. Jarrett, and H. Keen, Coronary Heart Disease risk and impaired glucose tolerance, Lancet, I:1373 (1980).CrossRefGoogle Scholar
  10. 10.
    E.A. Dupree, and M.B. Marter, Role of risk factors in complications of diabetes mellitus, Am. J. Epid., 112: 100 (1980).Google Scholar
  11. 11.
    K. Pyorala, Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland, Diabetes Care, 2: 131 (1979).PubMedCrossRefGoogle Scholar
  12. 12.
    R.W. Stout, Diabetes and Atherosclerosis. The role of Insulin., Diabetologia, 16: 141 (1979).PubMedCrossRefGoogle Scholar
  13. 13.
    S. Zattersquist, V. Bergvell, B. Linde, and B. Pernow, The validity of some conventional methods for the diagnosis of obliterative arterial disease in the lower limbs as evaluated by arteriography, Scand. J. Clin. Lab. Invest., 33: 633 (1971).Google Scholar
  14. 14.
    R. Fluckiger, and K.H. Winterhalter, In vitro synthesis of hemoglobin A1, FEBS Lett., 71:356 (1976).PubMedCrossRefGoogle Scholar
  15. 15.
    A. Cerami, V.J. Stevens, V.M. Monnier, Role of non enzymatic glycosilation in the development of sequelae of diabetes mellitus, Metabolism, 28 (Suppl. 1): 431 (1979).PubMedCrossRefGoogle Scholar
  16. 16.
    J.H. Fuller, H. Keen, R.J. Jarrett, T. Omer, T.W. Meade, R. Chakrabarti, W.R.S. North, and Y. Stirling, Haemostatic variables associated with diabetes and its complications, Br. M. J., 2: 964 (1979).CrossRefGoogle Scholar
  17. 17.
    C.T. Dollery, L.A. Friedman, C.N. Hansby, E.M. Kohner, P.J. Lewis, M. Porta, and J. Aebster, Circulating prostacyclin may be reduced in diabetes, Lancet, 2: 1365 (1979).PubMedCrossRefGoogle Scholar
  18. 18.
    R. Kawate, M. Yamakido, Y. NTshimoto, P.H. Bennett, R.F. Hammon, and W.C. Knowler, Diabetes Mellitus and its vascular complications in Japanes Migrants on the Island of Hawaii, Diabetes Care, 2: 161 (1979).PubMedCrossRefGoogle Scholar
  19. 19.
    A. Rivellese, G. Riccardi, A. Giacco, D. Pacioni, S. Genovese, P.L. Mattioli, and M. Mancini, Effect of dietary fibre on glucose control and serum lipoproteins in diabetic patients, Lancet, II: 447 (1980).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • M. Mancini
    • 1
  • G. Riccardi
    • 1
  • A. Rivellese
    • 1
  1. 1.Center for Arteriosclerosis and Metabolic Disease Semiotica Medica, 2nd Faculty of MedicineUniversity of NaplesNaplesItaly

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