Abstract
Hepatitis B virus (HBV) is the aetiological agent for the most widespread and virulent form of hepatitis in man. In some countries of the world, particularly tropical Africa and the Far East, the virus is endemic and the incidence of hepatitis is extremely high. It has long been observed that the frequency of primary liver cancer (PLC) is also unusually high among peoples of those particular countries (1). It has further been extensively documented that this frequency of liver cancer is correlated to previous infection with HBV and indeed, that PLC is commonly associated with the presence in the serum of HBs Ag, the major surface antigen of HBV and/or other HBV antigens and their corresponding antibodies (2). These observations lead to the obvious question of an aetiological role for HBV in malignant liver disease.
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References
W. Szmuness, E. J. Harley, H. Ikram and C. E. Stevens. Sociodemographic aspects of the epidemiology of hepatitis B: In Viral Hepatitis, G. N. Vyas, S. N. Cohen and R. Schmid, ed., Franklin Institute Press, Philadelphia, 297–320 (1978).
A. Goudeau, Ph. Maupas, P. Coursaget, J. Drucker, J. P. Chiron, F. Denis and I. Diopmar. Hepatitis B virus antigens in human primary hepatocellular carcinoma tissues. International Journal of Cancer 24, 421–429 (1979).
J. Summers, J. M. Smolec and R. Snyder. A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proceedings of the National Academy of Sciences, U.S.A. 75, 4533–4537 (1978).
P. L. Marion, L. Oshira, D. C. Regnery, G. H. Scullard and W. S. Robinson. A virus in Beechy ground Squirrels that is related to hepatitis B virus of humans. Proceedings of the National Academy of Sciences, U.S.A. 77, 2941–2945 (1980).
W. S. Mason, G. Seal and J. Summers. Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus. J. Virology 36, 82 9–836 (1980).
W. S. Robinson. The genome of hepatitis B virus. Annual Review of Microbiology 31, 357–377 (1977).
C. J. Burrell, P. Mackay, P. J. Greenaway, P. H. Hofschneider and K. Murray. Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR 322. Nature 279, 43–47 (1979).
P. Charnay, C. Pourcel, A. Louise, A. Fritsch and P. Tiollais. Cloning in Escherichia coli and physical structure of hepatitis B virion DNA. Proceedings of the National Academy of Sciences, U.S.A. 76, 2222–2226 (1979).
J. J. Sninsky, A. Siddiqui, W. S. Robinson and S. N. Cohen. Cloning and endonuclease mapping of the hepatitis B viral genome. Nature 279, 346–348 (1979).
I. W. Cummings, J. K. Browne, W. A. Salser, G. V. Tyler, R. L. Snyder, J. M. Smolec and J. Summers. Isolation, characterization, and comparison of recombinant DNAs derived from genomes of human hepatitis B virus and woodchuck hepatitis virus. Proceedings of the National Academy of Sciences, U.S.A. 77, 1842–1846 (1980).
E. M. Southern. Detection of specific sequences among DNA fragments separated by gel electro-phoresis. Journal of Molecular Biology 98, 503–517 (1975).
G. M. Macnab, J. J. Alexander, G. Lecatsas, E. M. Bey and J. M. Urbanowicz. Hepatitis B surface antigen produced by a human hepatoma cell line. British Journal of Cancer 34, 509–515 (1976).
D. P. Aden, A. Fogel, S. Plotkin, I. Damjanov and B. B. Knowles. Controlled synthesis of HBs Ag in a differentiated human liver carcinoma-derived cell line. Nature 282, 615–616 (1979).
C. Ruiming, Z. Dehou, Y. Xiuzheu, S. Dingwu and L. Ronghua. Establishment of three human liver carcinoma cell lines and some of their biological characteristics in vitro. Scientia Sinica 23, 236–247 (1980).
R. Koshy, R. Gallo and F. Wong-Staal. Characterization of the endogenous feline leukemia virus related DNA sequences in cats and attempts to identify exogenous viral sequences in tissues of virus negative leukemic animals. Virology 103, 434–445 (1980).
P. W. Rigby, M. A. Dieckmann, C. Rhodes and P. J. Berg. Labelling of deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. Journal of Molecular biology 113, 237–251 (1977).
P. L. Marion, F. H. Salazar, J. J. Alexander and W. S. Robinson. State of hepatitis B viral DNA in a human hepatoma cell line. Journal of Virology 33, 795–806 (1980).
C. Brechot, C. Pourcel, A. Louise, B. Rain and P. Tiollais. Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 286, 533–535 (1980).
P. R. Chakraborty, N. Ruiz-Opazo, D. Shouval and D. A. Shafritz. Identification of integrated hepatitis B viral DNA and expression of viral RNA in an HBs Ag-producing human hepatocellular carcinoma cell line. Nature 286, 531–533 (1980).
J. C. Edman, P. Gray, P. Valenzuela, L. B. Rail and W. J. Rutter. Integration of hepatitis B virus sequences and their expression in a human hepatoma cell. Nature 286, 535–538 (1980).
J. Tooze. The molecular biology of tumour viruses. Cold Spring Harbor publications. (1973).
J. Tooze. DNA tumour viruses. In Molecular Biology of Tumour Viruses. 2nd Edn. (1980).
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Koshy, R., Hofschneider, P.H. (1983). Hepatitis B Virus: Molecular Biology Studies on its Presumptive Role in Human Primary Liver Cancer. In: Chandra, P. (eds) Biochemical and Biological Markers of Neoplastic Transformation. NATO Advanced Science Institutes Series, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4454-4_47
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DOI: https://doi.org/10.1007/978-1-4684-4454-4_47
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