Hepatitis B Virus: Molecular Biology Studies on its Presumptive Role in Human Primary Liver Cancer

  • Rajen Koshy
  • Peter Hans Hofschneider
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


Hepatitis B virus (HBV) is the aetiological agent for the most widespread and virulent form of hepatitis in man. In some countries of the world, particularly tropical Africa and the Far East, the virus is endemic and the incidence of hepatitis is extremely high. It has long been observed that the frequency of primary liver cancer (PLC) is also unusually high among peoples of those particular countries (1). It has further been extensively documented that this frequency of liver cancer is correlated to previous infection with HBV and indeed, that PLC is commonly associated with the presence in the serum of HBs Ag, the major surface antigen of HBV and/or other HBV antigens and their corresponding antibodies (2). These observations lead to the obvious question of an aetiological role for HBV in malignant liver disease.


Primary Liver Cancer Pekin Duck Woodchuck Hepatitis Virus Malignant Liver Disease Subgenomic Fragment 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Rajen Koshy
    • 1
  • Peter Hans Hofschneider
    • 1
  1. 1.Abt. VirusforschungMax-Planck-Institut für BiochemieMartinsriedGermany

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