Immunological Control of EBV Infected B Cells

  • Eva Klein
  • George Klein
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


The majority of individuals harbors EB-virus infected B cells (BEBV), (For characteristics of the virus-cell and virus host relationship see references 1 and 2). When blood lymphocytes or tissues from donors who experienced virus infection are explanted, the BEBV cells grow and can be easily established as permanent lines — LCLEBV, lymphoblastoid cell lines. Limiting dilution experiments estimated 500–5,000 B cells with proliferative potential in the blood. In acute IM (infectious mononucleosis) the number is higher and cells that carry the viral genome and consequently express a nuclear antigen, EBNA, can be visually detected in the isolated B subset. Robinson et al. showed that these cells divide.3 In fatal IM cases EBNA positive cells were detected also in the spleen, liver and thymus.


Infectious Mononucleosis Immunological Control Viral Cycle Autologous Mixed Lymphocyte Reaction Host Range Mutant 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Eva Klein
    • 1
  • George Klein
    • 1
  1. 1.Department of Tumor BiologyKarolinska InstitutetStockholmSweden

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