Involvement of Herpes Simplex Virus in Cervical Carcinoma

  • Fred Rapp
  • Mary K. Howett
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


Cancer of the uterine cervix is the most common cancer of the reproductive system. Richart (1975) has stated that cervical intraepithelial neoplasia begins as a single-cell lesion at the squamocolumnar junction, more commonly on the anterior than on the posterior lip of the cervix, and only infrequently at the lateral angles. The progression in growth of lesions exhibiting irreversible malignant cellular changes advances from dysplasia to carcinoma in situ to invasive carcinoma. Massive screening of semi-annual cervical smears via Papanicolaou staining has resulted in increased detection of this cancer prior to invasion, and the cure rate of cancers detected at early stages (dysplasia or carcinoma in situ) is close to 100% (Gellman, 1976). However, women in lower socioeconomic groups and in Third World countries lack access to regular gynecologic examination and present with an increased incidence of invasive tumors. In the United States, the American Cancer Society estimates 16,000 new cases of invasive cervical cancer during 1981 and predicts 7,200 deaths (Table 1).


Cervical Cancer Cervical Carcinoma Cervical Intraepithelial Neoplasia Penile Cancer Verrucous Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Fred Rapp
    • 1
  • Mary K. Howett
    • 1
  1. 1.Department of Microbiology and Specialized Cancer Research CenterThe Pennsylvania State University College of MedicineHersheyUSA

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