Clinical Trials with a Partially Thiolated Polycytidylic Acid, a Potent Inhibitor of Retroviral Reverse Transcriptase, in the Treatment of Acute Childhood Leukemia
A partially thiolated polycytidylic acid, containing 5-mercapto substituted cytosine bases, abbreviated as MPC was found to inhibit the oncornaviral DNA polymerase in a very specific manner (Chandra and Bardos, 1972; Chandra, 1974; Chandra et al., 1975,1977,1980). Compared to the cellular DNA polymerases α, ß and γ, the activity of viral DNA polymerase was, by far, more sensitive to MPC (Chandra et al., 1979, 1980). The antileukemic effect of MPC was studied on FLV-induced leukemia (Chandra et al., 1977, 1979), and under vitro-vivo conditions it was found to be very effective. Toxicological studies have shown that the compound is not mutagenic in Ames test, and does not produce any chromosomal abnormalities in mice and rats (unpublished results).
KeywordsChildhood Leukemia Ames Test Leukemic Case Acute Childhood Leukemia Polycytidylic Acid
Unable to display preview. Download preview PDF.
- Chandra, P. (1974): In, Topics in Current Chem., Springer Verlag Berlin-Heidelberg-New York, Vol 52, 99–139.Google Scholar
- Chandra, P. and Bardos, T.J. (1972): Res. Commun. Chem. Pathol, and Pharmacol. 4, 615–622.Google Scholar
- Chandra, P., Ebener, U., Bardos, T.J., Gericke, D., Kornhuber, B., Götz, A. (1977): Fogarty International Center Proceedings (USA) 28, 16 9–186.Google Scholar
- Chandra, P., Ebener, U. and Gericke, D. (1979): In, Antiviral Mechanisms in the Control of Neoplasia (Ed. P. Chandra), Plenum Press, N.Y. 523–538.Google Scholar
- Chandra, P., Steel, L.K., Ebener, U., Woltersdorf, M., Laube, H., Kornhuber, B., Mildner, B., Götz, A. (1980):. Intnl.Encycl.Pharm.Ther. Section 1. 03, 47–90Google Scholar
- Haddow, A. (1947): Growth JM, 339.Google Scholar
- Rhiem, H., Gardner, H., Jessenberger, K. and Tariverdian, G. (1974): Proc.Amer.Assoc.Cancer Res. 15, 58.Google Scholar