Clinical Trials with a Partially Thiolated Polycytidylic Acid, a Potent Inhibitor of Retroviral Reverse Transcriptase, in the Treatment of Acute Childhood Leukemia

  • Bernhard Kornhuber
  • Prakash Chandra
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


A partially thiolated polycytidylic acid, containing 5-mercapto substituted cytosine bases, abbreviated as MPC was found to inhibit the oncornaviral DNA polymerase in a very specific manner (Chandra and Bardos, 1972; Chandra, 1974; Chandra et al., 1975,1977,1980). Compared to the cellular DNA polymerases α, ß and γ, the activity of viral DNA polymerase was, by far, more sensitive to MPC (Chandra et al., 1979, 1980). The antileukemic effect of MPC was studied on FLV-induced leukemia (Chandra et al., 1977, 1979), and under vitro-vivo conditions it was found to be very effective. Toxicological studies have shown that the compound is not mutagenic in Ames test, and does not produce any chromosomal abnormalities in mice and rats (unpublished results).


Childhood Leukemia Ames Test Leukemic Case Acute Childhood Leukemia Polycytidylic Acid 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Bernhard Kornhuber
    • 1
  • Prakash Chandra
    • 1
  1. 1.Zentrum der Kinderheilkunde und Zentrum der Biolog.-ChemieKlinikum der UniversitätFrankfurt/M.70Deutschland

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