Properties of an RNA Retrovirus Continuously Produced at Low Levels by a Human Histiocytic Lymphoma Cell Line
Type-C RNA viruses (retroviruses) are capable of inducing leukemias, lymphomas, and sarcomas in several mammalian species, including mice, cats, guinea pigs, cattle, and subhuman primates (Kaplan 1974), suggesting that they may also be involved in the etiology of these types of neoplasms in man. Retroviruses have been detected in culture fluids after short-term culture of hematopoietic cells of patients with leukemias (Gallagher and Gallo, 1975; Nooter et al.,1975; Teich et al., 1975) and of diploid human embryonic cell strains (Panem et al., 1975).
KeywordsLymphoma Cell Line Reverse Transcriptase Activity Peripheral Blood Mononuclear Histiocytic Lymphoma Supernatant Culture Fluid
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