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The Cloning and Analyses of Human Cellular Genes Homologous to Retroviral Onc Genes

  • Flossie Wong-Staal
  • Eric Westin
  • Genoveffa Franchini
  • Edward Gelmann
  • Riccardo Dalla Favera
  • Vittorio Manzari
  • Robert C. Gallo
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)

Abstract

Type-C retroviruses are associated with certain forms of naturally occurring leukemias and lymphomas of many species, including humans, as recently evidenced. These viruses generally do not transform cells directly in vitro and apparently do not contain a specific transforming gene. In contrast, a more unusual class of retroviruses is the acutely transforming viruses1,2. They cause diseases rapidly in vivo, have the capacity to transform appropriate target cells in vitro, and contain genomes which are usually defective for replication and include a specific transforming (v-onc) gene.

Keywords

Long Terminal Repeat Cellular Gene Rous Sarcoma Virus Woolly Monkey Human Hematopoietic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Flossie Wong-Staal
    • 1
  • Eric Westin
    • 1
  • Genoveffa Franchini
    • 1
  • Edward Gelmann
    • 1
  • Riccardo Dalla Favera
    • 1
  • Vittorio Manzari
    • 1
  • Robert C. Gallo
    • 1
  1. 1.Laboratory of Tumor Cell BiologyNational Cancer InstituteBethesdaUSA

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