Tumor Antigens and Transformation-Related Proteins Associated with Feline Retroviruses

  • M. Essex
  • A. P. Chen
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


The oncogenic feline retroviruses that cause leukemia, lymphoma, and fibrosarcoma have been defined in detail. The feline leukemia virus (FeLV) a replication-competent agent, causes leukemia, lymphoma, and aplastic anemia, as well as a syndrome of immunosuppression which predisposes cats to the development of numerous other infectious diseases (Essex, 1975). FeLV will not transform fibroblasts. The tumors induced by FeLV occur after a prolonged induction period (Francis, et al., 1979b), and they are monoclonal (Mullins, personal communication). The feline sarcoma virus (FeSV), which is defective for replication, can only be transmitted from cell to cell in the presence of FeLV. FeSV will transform cultured fibroblasts with a very high degree of efficiency. When FeSV is inoculated into kittens, it usually causes multicentric fibrosarcomas. These tumors are polyclonal in origin and they occur after a very brief latent period (Snyder and Theilen, 1969).


Aplastic Anemia Feline Leukemia Virus Cell Membrane Antigen Nonproducer Cell Tryptic Peptide Mapping 


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • M. Essex
    • 1
  • A. P. Chen
    • 1
  1. 1.Department of MicrobiologyHarvard University School of Public HealthBostonUSA

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