Nucleotide Sequence Analysis of Integrated Avian Myeloblastosis Virus (AMV) Long Terminal Repeat (LTR) and Their Host and Viral Junctions: Structural Similarities to Transposable Elements
The nucleotide sequence of the integrated avian myeloblastosis virus (AMV) long terminal repeat (LTR) has been determined. The sequence is 385 bp long and is present at both ends of the viral DNA. The cell-virus junctions at each end consist of a six base pair direct repeat of cell DNA next to the inverted repeat of viral DNA, The LTR also contains promoter-like sequences, a mRNA capping site, and polyadenylation signals. Several features of this LTR suggest a structural and functional similarity with sequences of transposable and other genetic elements. Comparison of these sequences with LTRs of other avian retroviruses indicates that there is a great variation in the 3′ unique sequence (U3) while the 5′ specific sequences are highly conserved.
KeywordsTransposable Element Long Terminal Repeat Inverted Repeat Rous Sarcoma Virus Avian Mye1ob1astosis Virus
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