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Immunological Markers of Human Leukemic Cells of the B Lineage

  • M. Seligmann
  • L. B. Vogler
  • P. Guglielmi
  • J. C. Brouet
  • J. L. Preud’homme
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)

Abstract

The study of immunological cell markers in human leukemias and lymphomas has made it possible to establish the nature and origin of the proliferating cells and to demonstrate the heterogeneity of many conditions which appeared previously rather homogeneous to the hematologist. Since leukemic cells usually appear to be frozen at a given stage along the differentiation pathway, these studies have also provided important insights into the biology of the progenitors of hematopoietic cells which correspond to the normal counterpart of the leukemic cell. The maturation arrest characteristic of many human leukemic cells can sometimes be reverted after in vitro stimulation. Such studies may eventually lead to an understanding of crucial differences between the regulation of normal and leukemic cells.

Keywords

Chronic Lymphocytic Leukemia Hairy Cell Leukemia Chronic Lymphocytic Leukemia Cell Human Leukemic Cell Hairy Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • M. Seligmann
    • 1
  • L. B. Vogler
    • 1
  • P. Guglielmi
    • 1
  • J. C. Brouet
    • 1
  • J. L. Preud’homme
    • 1
  1. 1.Laboratory of Immunochemistry and Immunopathology (INSERM U 108, Research Institute of Blood Diseases and Laboratory of Oncology and Immunohematology of CNRS)Hôpital Saint-LouisParisFrance

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