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Glucocorticoid Receptors and Sensitivity in Normal and Neoplastic Human Lymphoid Tissues

  • Françoise Homo
  • Sylvie Durant
  • Dominique Duval
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)

Abstract

It has been known for a long time that glucocorticoids exert many physiological and pharmacological effects on mammalian lymphoid tissues. In vivo, administration of corticosteroids or adrenalectomy have been shown to induce marked changes in the size of lymphoid organs as well as in lymphocyte circulation and to alter many immunological reactions (1). In vitro, glucocorticoids are generally considered as catabolic agents that induce an inhibition of membrane transports and macromolecules synthesis leading to an arrest of cell growth sometimes accompanied by cell lysis (2). These compounds are also able to modify several immunological functions in vitro (3).

Keywords

Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia Glucocorticoid Receptor Chronic Lymphocytic Leukemia Patient Null Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    HN Claman, Corticosteroids and lymphoid cells, New Engl J Med 287: 388 (1972).CrossRefGoogle Scholar
  2. 2.
    A Munck and DA Young, Corticosteroids and lymphoid tissue, in: Handbook of Physiology, Section Endocrinology, vol 6 Adrenal Gland, SR Geiger, ed., American Physiological Society, Washington, pp. 231–243 (1975).Google Scholar
  3. 3.
    JF Bach, Corticosteroids, in: The Mode of Action of Immunosuppressive Agents, A Neuberger & EL Tatum, eds., Frontiers of Biology, vol 41, North Holland Publishing Co, Amsterdam, pp. 21–91 (1975).Google Scholar
  4. 4.
    A Munck and K Leung, Glucocorticoid receptors and mechanisms of action, in: Receptors and Mechanism of Action of Steroid Hormones, Part II, JR Pasqualini, ed., Marcel Dekker, New York, pp. 311–397 (1977).Google Scholar
  5. 5.
    J Caffey and R Sibley, Regrowth and overgrowth of the thymus after atrophy induced by the oral administration of adrenocorticosteroids to human infants, Pediatrics 26: 762 (1960).Google Scholar
  6. 6.
    HN Claman, JW Moorhead and WH Benner, Corticosteroids and lymphoid cells in vitro. I. Hydrocortisone lysis of human, guinea pig and mouse thymus cells, J Lab Clin Med 78: 499 (1971).Google Scholar
  7. 7.
    U Galili, M Prokocimer and G Izak, The in vitro sensitivity of leukemic and normal leukocytes to hydrocortisone induced cytolysis, Blood 56: 1077 (1980).Google Scholar
  8. 8.
    F Homo and D Duval, Human thymus cells: effects of glucocorticoids in vitro, J Clin Lab Immunol 2: 329 (1979).Google Scholar
  9. 9.
    AS Fauci and DC Dale, The effect of in vivo hydrocortisone on subpopulations of human lymphocytes, J Clin Invest 53: 240 (1974).CrossRefGoogle Scholar
  10. 10.
    AS Fauci, T Murakami, DD Brandon, DL Loriaux and MB Lipsett, Mechanisms of corticosteroid action on lymphocyte subpopulations. VI. Lack of correlation between glucocorticosteroid receptors and the differential effects of glucocorticosteroids on T cell subpopulations, Cell Immunol 49: 43 (1980).CrossRefGoogle Scholar
  11. 11.
    AS Fauci, Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and B lymphocytes to the bone marrow, Immunology 28: 669 (1975).Google Scholar
  12. 12.
    R Schreck, Cytotoxicity of adrenal cortex hormones on normal and malignant lymphocytes of man and rat, Proc Soc Exp Biol (NY) 108: 326 (1961).Google Scholar
  13. 13.
    F Homo, D Duval, C Thierry and B Serrou, Human lymphocyte sub- populations: effects of glucocorticoids in vitro, J Steroid Biochem 10: 609 (1979).CrossRefGoogle Scholar
  14. 14.
    GR Crabtree, KA Smith and A Munck, Glucocorticoid receptors and in vitro sensitivity of cells from patients with leukemia and lymphoma: a reassessment, in: Glucocorticoid Action and Leukemias, PA Bell and NM Borthwick, eds., Seventh Tenovus Workshop, Alpha Omega Publishing Ltd, Cardiff, pp. 191–204, (1979).Google Scholar
  15. 15.
    ME Lippman and R Barr, Glucocorticoid receptors in purified subpopulations of human peripheral blood lymphocytes, J Immunol 118: 1977 (1977).Google Scholar
  16. 16.
    ME Lippman, RH Halterman, BG Leventhal, S Perry and EB Thompson, Glucocorticoid binding proteins in human acute lymphoblastic leukemic blast cells, J Clin Invest 52: 1715 (1973).CrossRefGoogle Scholar
  17. 17.
    P Nanni, C De Giovanni, MC Galli, G Nicoletti, PL Lollini, M Gobbi, S Bartoli and S Grilli, Glucocorticoid binding protein occurrence and glucocorticoid sensitivity in cells from human acute lymphoblastic leukaemia, IRCS Medical Science 8: 624 (1980).Google Scholar
  18. 18.
    AD Ho, W Hunstein and W Schmid, Glucocorticoid receptors and sensitivity in leukemias, Blut 42: 183 (1981).CrossRefGoogle Scholar
  19. 19.
    K Kontula, LC Andersson, T Paavonen, G Myllyla, L Teerenhovi and P Vuopio, Glucocorticoid receptors and glucocorticoid sensitivity of human leukemic cells, Int J Cancer 26: 177 (1980).CrossRefGoogle Scholar
  20. 20.
    J Schlechte and B Sherman, The glucocorticoid receptor. Regulation by hormone administration, The Endocrine Society, 63rd Annual Meeting, abstract 694 (1981).Google Scholar
  21. 21.
    LA Hansson, SA Gustafsson, J Carlstedt-Duke, G Gahrton, B Hogberg and JA Gustafsson, Quantitation of the cytosolic glucocorticoid receptor in human normal and neoplastic leukocytes using isoelectric focusing in polyacrylamide gel, J Steroid Biochem 14: 757 (1981).CrossRefGoogle Scholar
  22. 22.
    T Werb, R Foley and A Munck, Interaction of glucocorticoids with macrophages. Identification of glucocorticoid receptors in monocytes and macrophages, J Exp Med 147: 1684 (1978).CrossRefGoogle Scholar
  23. 23.
    CW Distelhorst and BM Benutto, Glucocorticoid receptor content of T lymphocytes: evidence for heterogeneity, J Immunol 126: 1630 (1981).Google Scholar
  24. 24.
    J Ahlquist, The adrenal cortex, in: Endocrine Influences on Lymphatic Organs, Immune Responses, Inflammation and Autoimmunity, Almquist and Wiksell International, Stockholm, pp. 18–30 (1976).Google Scholar
  25. 25.
    CD Bloomfield, KA Smith, L Hilde-Brandt, J Zaleskas, KJ Gajl-Peczalska, G Frizzera, BA Peterson, JM Kersey, GR Crabtree and A Munck, The therapeutic utility of glucocorticoid receptor studies in non-Hodgkin’s malignant lymphoma, in: Hormones and Cancer, S Iacobelli, ed., Raven Press, New York, pp. 345–359 (1980).Google Scholar
  26. 26.
    FO Ranelletti, M Carmignani, S Iacobelli and P Tonali, Glucocorticoid-binding components in human thymus hyperplasia, Cancer Res 38: 516 (1978).Google Scholar
  27. 27.
    JG Leinen, JL Wittliff, JA Kostyu and RC Brown, Glucocorticoid-binding components in an irradiation-induced thymoma of the C57BL/6J mice, Cancer Res 34: 2779 (1974).Google Scholar
  28. 28.
    FO Ranelletti, S Iacobelli, M Carmignani, G Sica, C Natoli and P Tonali, Glucocorticoid receptors and in vitro corticosensitivity in human thymoma, Cancer Res 40: 2020 (1980).Google Scholar
  29. 29.
    S Iacobelli, P Longo, R Mastrangelo, R Malandrino and FO Ranelletti, Glucocorticoid receptors and steroid sensitivity of acute lymphoblastic leukemia and thymoma, in: Hormones and Cancer, S Iacobelli et al., eds., Raven Press, New York, pp. 371–385 (1980).Google Scholar
  30. 30.
    F Homo, M Papiernik and F Russo-Marie, Steroid modulation of in vitro prostaglandin secretion by human thymic epithelium, J Steroid Biochem (in press).Google Scholar
  31. 31.
    CC Bird, Clinical classification of leukaemia and lymphoma in relation to glucocorticoid therapy, in: Glucocorticoid Action and Leukaemia, PA Bell and NM Borthwick, eds., 7th Tenovus Workshop, Alpha Omega Publishing Ltd, Cardiff, pp. 123–142 (1979).Google Scholar
  32. 32.
    KA Foon, RJ Billing, PI Terasaki and MJ Cline, Immunologic classification of acute lymphoblastic leukemia. Implications for normal lymphoid differentiation, Blood 56: 1120 (1980).Google Scholar
  33. 33.
    WL McGuire, An update on estrogen and progesterone receptors in prognosis for primary and advanced breast cancer, in: Hormones and Cancer, S Iacobelli et al., eds., Raven Press, New York, pp. 337–343 (1980).Google Scholar
  34. 34.
    S Galaini, J Minowada, P Silvernail, A Nussbaum, N Kaiser, F Rosen and K Shimaoka, Specific glucocorticoid binding in human hemopoietic cell lines and neoplastic tissue, Cancer Res 33: 2653 (1973).Google Scholar
  35. 35.
    F Homo, D Duval, JL Harousseau, JP Marie and R Zittoun, Heterogeneity of the in vitro responses to glucocorticoids in acute leukemia, Cancer Res 40: 2601 (1980).Google Scholar
  36. 36.
    R Mastrangelo, R Malandrino, R Riccardi, P Longo, FO Ranelleti and S Iacobelli, Clinical implications of glucocorticoid receptor studies in childhood acute lymphoblastic leukemia, Blood 56: 1036 (1980).Google Scholar
  37. 37.
    A Naray, T Revesz, E Walcz, D Schüler and I Horvath, Glucocorticoid receptors in acute leukemia of chidhood, Orv Hetil 121: 3175 (1980).Google Scholar
  38. 38.
    L Danel, P Martin, E Escrich, N Tubiana, D Fière and S Saez, Androgen, estrogen and progestin binding sites in human leukemic cells, Int J Cancer 27: 7 33 (1981).Google Scholar
  39. 39.
    GS Konior Yarbro, ME Lippman, GE Johnson and BG Leventhal, Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia, Cancer Res 37: 2688 (1977).Google Scholar
  40. 40.
    S Iacobelli, Personal communication.Google Scholar
  41. 41.
    ME Lippman, GS Konior Yarbro and BG Leventhal, Glucocorticoid receptors in normal and leukaemic human leucocytes, in: Glucocorticoid Action and Leukaemia, PA Bell and NM Borthwick, eds., Alpha Omega Publishing Ltd, Cardiff, pp. 175–190 (1979).Google Scholar
  42. 42.
    L Skoog, B Nordenskjöld, A öst, B Andersson, R Hast, N Giannoulis, S Humla, T Hägerström and P Reizenstein, Glucocorticoid receptor concentrations and terminal transferase activity as indicators of prognosis in acute non-lymphocytic leukaemia, Brit Med J 282: 1826 (1981).CrossRefGoogle Scholar
  43. 43.
    F Homo, D Duval, P Meyer, F Belas, P Debré and JL Binet, Chronic lymphatic leukaemia: cellular effects of glucocorticoids in vitro, Brit J Haematol 38: 491 (1978).CrossRefGoogle Scholar
  44. 44.
    L Terenius, B Simonsson and K Nilsson, Glucocorticoid receptors, DNA-synthesis, membrane antigens and their relation to disease activity in chronic lymphatic leukemia, J Steroid Biochem 7: 905 (1976).CrossRefGoogle Scholar
  45. 45.
    J Stevens, YW Stevens, E Sloan, R Rosenthal and J Rhodes, Nuclear glucocorticoid binding in chronic lymphatic leukemia lymphocytes, Endocrine Res Comm 5: 91 (1978).CrossRefGoogle Scholar
  46. 46.
    J Stevens, YW Stevens and RL Rosenthal, Characterization of cytosolic and nuclear glucocorticoid-binding components in human leukemic lymphocytes, Cancer Res 39: 4939 (1979).Google Scholar
  47. 47.
    JC Sloman and PA Bell, Glucocorticoids and myeloid leukaemia, in: Glucocorticoid Action and Leukemia, PA Bell and NM Borthwick, eds., Seventh Tenovus Workshop, pp. 161-169, Alpha Omega Publishing Ltd, Cardiff, pp. 161–169 (1979).Google Scholar
  48. 48.
    R Schreck, Prednisolone sensitivity and cytology of viable lymphocytes as tests for chronic lymphocytic leukemia, J Natl Cancer Inst 33: 837 (1964).Google Scholar
  49. 49.
    CD Bloomfield, KA Smith, BA Peterson, L Hildebrandt, J Zaleskas, KJ Gajl-Peczalska, G Frizzera and A Munck, In vitro glucocorticoid studies for predicting response to glucocorticoid therapy in adults with malignant lymphoma, Lancet 1: 952 (1980).CrossRefGoogle Scholar
  50. 50.
    TJ Schmidt and EB Thompson, Glucocorticoid receptors and glutamine synthetase in leukemic Sezary cells, Cancer Res 39: 376 (1979).Google Scholar
  51. 51.
    ME Lippman, S Perry and EB Thompson, Cytoplasmic glucocorticoid-binding proteins in glucocorticoid-unresponsive human and mouse leukemic cell lines, Cancer Res 34: 1572 (1974).Google Scholar
  52. 52.
    MR Norman and EB Thompson, Characterization of a glucocorticoid-sensitive human lymphoid cell line, Cancer Res 37: 3785 (1977).Google Scholar
  53. 53.
    CC Bird, AW Waddell, AMG Robertson, AR Currie, CM Steel and J Evans, Cytoplasmic receptor levels and glucocorticoid response in human lymphoblastoid cell lines, Br J Cancer 33: 700 (1976).Google Scholar
  54. 54.
    T Paavonen, LC Andersson and K Kontula, Lack of correlation between the glucocorticoid receptor density and the in vitro growth-inhibitory effect of dexamethasone in human leukemic cell lines, J Receptor Res 1: 459 (1980).Google Scholar
  55. 55.
    ID Barrett, NS Panesar, CC Bird, AC Abbott, HM Burrow and CM Steel, Human lymphoid cell lines and glucocorticoids: II. Whole cell and cytoplasmic binding properties of lymphoblastoid, leukaemia and lymphoma lines, Diagnostic Histopathology 4: 189 (1981).Google Scholar
  56. 56.
    D Duval and F Homo, Prognostic value of steroid receptor deter-mination in leukemia, Cancer Res 38: 4263 (1978).Google Scholar
  57. 57.
    S Iacobelli, V Natoli, P Longo, F0 Ranelletti, G de Rossi, D Pasqualetti, F Mandelli and R Mastrangelo, Glucocorticoid receptor determination in leukemia patients using cytosol and whole cell assays, Cancer Res (in press).Google Scholar
  58. 58.
    EB Thompson, Report on the international union against cancer, Workshop on Steroid Receptors in Leukemia, Cancer Treatment Reports 63: 189 (1979).Google Scholar
  59. 59.
    D Duval and J Simon, Temperature-dependent changes in specificity of glucocorticoid receptors in mouse thymocytes, in: Multiple Molecular Forms of Steroid Hormone Receptors, MK Agarwal, ed., Elsevier/North Holland, Amsterdam, pp. 229–243 (1977).Google Scholar
  60. 60.
    F Svec and M Rudis, Glucocorticoids regulate the glucocorticoid receptor in the AtT-20 cell, J Biol Chem 256: 5984 (1981).Google Scholar
  61. 61.
    DB Endres, RJ Milholland and F Rosen, Sex differences in the concentrations of glucocorticoid receptors in rat liver and thymus, J Endocr 80: 21 (1979).CrossRefGoogle Scholar
  62. 62.
    P Coulson, D Skafar, S Seaver and J Thornthwaite, Dihydrotestosterone modulation of glucocorticoid receptor levels in thymus and bursa of Fabricius cells in immature chickens, The Endocrine Society, 63rd Annual Meeting, Abstract 692 (1981).Google Scholar
  63. 63.
    GR Crabtree, A Munck and K Smith, Glucocorticoids and lymphocytes. II. Cell cycle-dependent changes in glucocorticoid receptor content, J Immunol 125: 13 (1980).Google Scholar
  64. 64.
    JP Neifeld, ME Lippman and DC Torney, Steroid hormone receptors in normal human lymphocytes. Induction of glucocorticoid receptor activity by phytohemagglutinin, J Biol Chem 252: 297 2 (1977).Google Scholar
  65. 65.
    KA Smith, GR Crabtree, SJ Kennedy and AU Munck, Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unstimulated human lymphocytes, Nature 267: 523 (1977).CrossRefGoogle Scholar
  66. 66.
    AM Mauer and O Fisher, Comparison of the proliferative capacity of acute leukemia cells in bone marrow and blood, Nature 193: 1085 (1962).CrossRefGoogle Scholar
  67. 67.
    F Homo, S Durant, D Duval, JP Marie, R Zittoun and JL Harousseau, In vitro hormonal responsiveness of human blood and bone marrow cells in non-lymphocytic leukemia, Leukemia Res 4: 619 (1980).CrossRefGoogle Scholar
  68. 68.
    AF Kirkpatrick, RJ Milholland and F Rosen, Stereospecific glucocorticoid binding to subcellular fractions of the sensitive and resistant lymphosarcoma P1798, Nature New Biol 232: 216 (1971).Google Scholar
  69. 69.
    W Rosenau, JD Baxter, GG Rousseau and GM Tomkins, Mechanism of resistance to steroids: glucocorticoid receptor defect in lymphoma cells, Nature New Biol 237: 20 (1972).Google Scholar
  70. 70.
    ML Nicholson and DA Young, An effect of glucocorticoid hormones in vitro on the structural integrity of nuclei in corticoid-sensitive and resistant lines of lymphosarcoma P1798, Cancer Res 38: 3673 (1978).Google Scholar
  71. 71.
    S Gillis, GR Crabtree and KA Smith, Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation, J Immunol 123: 1624 (1979).Google Scholar
  72. 72.
    KA Foon, RJ Billing, PI Terasaki and MJ Cline, Immunologic classification of acute lymphoblastic leukemia implications for normal lymphoid differentiation, Blood 56: 1120 (1980).Google Scholar
  73. 73.
    Y Nakao, S Tsuboi, T Fujita, T Masaoka, S Morikawa and S Watanabe, Glucocorticoid receptors and terminal deoxynucleotidyl transferase activities in leukemic cells, Cancer 47: 1812 (1981).CrossRefGoogle Scholar
  74. 74.
    P de Moor and A Louwagie, Association of aberrant transcortin levels with HLA antigens of the B and C loci: high transcortin levels are frequently found in patients with lymphatic leukemia, Hairy cell leukemia, or non-Hodgkin lymphoma, J Clin Endocrinol Metab 51: 868 (1980).CrossRefGoogle Scholar
  75. 75.
    B Becker, DH Shin, PF Palmberg and SR Waltman, HLA antigens and corticosteroid response, Science 194: 1427 (1976).CrossRefGoogle Scholar
  76. 76.
    MS Butley, RP Erickson and WB Pratt, Hepatic glucocorticoid receptors and the H-2 locus, Nature 275: 136 (1978).CrossRefGoogle Scholar
  77. 77.
    AD Forker, RE Bolinger, JH Morris and WE Larson, Metabolism of cortisol-C14 by human peripheral leucocyte cultures from leukemic patients, Metabolism 12: 75 (1963)1.Google Scholar
  78. 78.
    JS Jenkins and NH Kemp, Metabolism of Cortisol by human leukemic cells, J Clin Endocr 29: 1217 (1969).CrossRefGoogle Scholar
  79. 79.
    A Klein, H Kaufmann, S Mannheimer and H Joshua, Cortisol metabolism in lymphocytes from cancer-bearing patients, Metabolism 27: 731 (1978).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Françoise Homo
    • 1
  • Sylvie Durant
    • 1
  • Dominique Duval
    • 1
  1. 1.Dept of Nephrology Hôpital NeckerINSERM U7/CNRS LA 318ParisFrance

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