Glucocorticoid Receptors and Sensitivity in Normal and Neoplastic Human Lymphoid Tissues

  • Françoise Homo
  • Sylvie Durant
  • Dominique Duval
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


It has been known for a long time that glucocorticoids exert many physiological and pharmacological effects on mammalian lymphoid tissues. In vivo, administration of corticosteroids or adrenalectomy have been shown to induce marked changes in the size of lymphoid organs as well as in lymphocyte circulation and to alter many immunological reactions (1). In vitro, glucocorticoids are generally considered as catabolic agents that induce an inhibition of membrane transports and macromolecules synthesis leading to an arrest of cell growth sometimes accompanied by cell lysis (2). These compounds are also able to modify several immunological functions in vitro (3).


Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia Glucocorticoid Receptor Chronic Lymphocytic Leukemia Patient Null Cell 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Françoise Homo
    • 1
  • Sylvie Durant
    • 1
  • Dominique Duval
    • 1
  1. 1.Dept of Nephrology Hôpital NeckerINSERM U7/CNRS LA 318ParisFrance

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