Regulation of Cytidine Uptake in Ehrlich Ascites Tumour Cells
Cunningham and Pardee (1969) have described that dialyzed serum is able to stimulate the uptake of uridine in contact-inhibited 3T3 cells. Since then, a large number of studies have been published to describe the effect of hormones, cyclic nucleotides, lectins and viral transformation on the uptake of nucleosides and other nutrients (for reviews see Plagemann and Richey, 1974; Wohlhueter and Plagemann, 1980; Plagemann and Wohlhueter, 1980). In most of these studies, the control mechanism investigated was based on the regulation of de novo formation or breakdown of the proteins presumably involved in nucleoside uptake, i. e. the transmembrane transport catalyzing carrier, and the nucleoside kinase which phosphorylates, and thereby traps, the substrate within the cell.
KeywordsCytosine Arabinoside High Substrate Concentration Nucleoside Transport Ehrlich Ascites Tumour Cell Transport Component
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